Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids

  1. Costantini, David ORCID logo
  2. Seeber, Peter Andreas ORCID logo
  3. Soilemetzidou, Sanatana-Eirini
  4. Azab, Walid ORCID logo
  5. Bohner, Julia
  6. Buuveibaatar, Bayarbaatar
  7. Czirják, Gábor Árpád ORCID logo
  8. East, Marion ORCID logo
  9. Greunz, Eva Maria
  10. Kaczensky, Petra ORCID logo
  11. Lamglait, Benjamin
  12. Melzheimer, Joerg ORCID logo
  13. Uiseb, Kenneth
  14. Ortega, Alix
  15. Osterrieder, Nikolaus
  16. Sandgreen, Ditte-Mari
  17. Simon, Marie
  18. Walzer, Chris
  19. Greenwood, Alex ORCID logo

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WeightNameValue
1000 Titel
  • Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids
1000 Autor/in
  1. Costantini, David |
  2. Seeber, Peter Andreas |
  3. Soilemetzidou, Sanatana-Eirini |
  4. Azab, Walid |
  5. Bohner, Julia |
  6. Buuveibaatar, Bayarbaatar |
  7. Czirják, Gábor Árpád |
  8. East, Marion |
  9. Greunz, Eva Maria |
  10. Kaczensky, Petra |
  11. Lamglait, Benjamin |
  12. Melzheimer, Joerg |
  13. Uiseb, Kenneth |
  14. Ortega, Alix |
  15. Osterrieder, Nikolaus |
  16. Sandgreen, Ditte-Mari |
  17. Simon, Marie |
  18. Walzer, Chris |
  19. Greenwood, Alex |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-07-09
1000 Erschienen in
1000 Quellenangabe
  • 8:10347
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-018-28688-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037783/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse (Equus ferus caballus) and of both captive and free-ranging Mongolian khulan (Equus hemionus hemionus) and plains zebra (Equus quagga). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations.
1000 Sacherschließung
lokal Pathogens
lokal Ecophysiology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8140-8790|https://orcid.org/0000-0003-4401-8248|https://frl.publisso.de/adhoc/uri/U29pbGVtZXR6aWRvdSwgU2FuYXRhbmEtRWlyaW5p|https://orcid.org/0000-0003-2880-7255|https://frl.publisso.de/adhoc/uri/Qm9obmVyLCBKdWxpYQ==|https://frl.publisso.de/adhoc/uri/QnV1dmVpYmFhdGFyLCBCYXlhcmJhYXRhcg==|https://orcid.org/0000-0001-9488-0069|https://orcid.org/0000-0002-0391-8365|https://frl.publisso.de/adhoc/uri/R3JldW56LCBFdmEgTWFyaWE=|https://orcid.org/0000-0001-5428-1176|https://frl.publisso.de/adhoc/uri/TGFtZ2xhaXQsIEJlbmphbWlu|https://orcid.org/0000-0002-3490-1515|https://frl.publisso.de/adhoc/uri/VWlzZWIsIEtlbm5ldGg=|https://frl.publisso.de/adhoc/uri/T3J0ZWdhLCBBbGl4|https://frl.publisso.de/adhoc/uri/T3N0ZXJyaWVkZXIsIE5pa29sYXVz|https://frl.publisso.de/adhoc/uri/U2FuZGdyZWVuLCBEaXR0ZS1NYXJp|https://frl.publisso.de/adhoc/uri/U2ltb24sIE1hcmll|https://frl.publisso.de/adhoc/uri/V2FsemVyLCBDaHJpcw==|https://orcid.org/0000-0002-8249-1565
1000 Label
1000 Förderer
  1. Leibniz-Gemeinschaft |
  2. Alexander von Humboldt-Stiftung |
  3. Wildlife Conservation Society |
1000 Fördernummer
  1. SAW-2015-IZW-1 440
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. Research Group Linkage Program
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2015-IZW-1 440
  2. 1000 joinedFunding-child
    1000 Förderer Alexander von Humboldt-Stiftung |
    1000 Förderprogramm Research Group Linkage Program
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Wildlife Conservation Society |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415008.rdf
1000 Erstellt am 2019-07-03T13:56:26.232+0200
1000 Erstellt von 218
1000 beschreibt frl:6415008
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2021-11-18T17:05:28.595+0100
1000 Objekt bearb. Thu Nov 18 17:05:28 CET 2021
1000 Vgl. frl:6415008
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415008 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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