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Hopfner-et-al_2019_No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.pdf 544,75KB
WeightNameValue
1000 Titel
  • No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors
1000 Autor/in
  1. Höpner, Franziska |
  2. Müller, Stefanie H. |
  3. Steppard, Dagmar |
  4. Miller, Joanna |
  5. Schmidt, Nele |
  6. Wandinger, Klaus-Peter |
  7. Leypoldt, Frank |
  8. Berg, Daniela |
  9. Franke, Andre |
  10. Lieb, Wolfgang |
  11. Tittmann, Lukas |
  12. Balzer-Geldsetzer, Monika |
  13. Baudrexel, Simon |
  14. Dodel, Richard |
  15. Hilker-Roggendorf, Rüdiger |
  16. Kalbe, Elke |
  17. Kassubek, Jan |
  18. Klockgether, Thomas |
  19. Liepelt-Scarfone, Inga |
  20. Mollenhauer, Brit |
  21. Neuser, Petra |
  22. Reetz, Kathrin |
  23. Riedel, Oliver |
  24. Schulte, Claudia |
  25. Schulz, Jörg B. |
  26. Spottke, Annika |
  27. Storch, Alexander |
  28. Trenkwalder, Claudia |
  29. Wittchen, Hans-Ulrich |
  30. Witt, Karsten |
  31. Wüllner, Ullrich |
  32. Deuschl, Günther |
  33. Kuhlenbäumer, Gregor |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-04-03
1000 Erschienen in
1000 Quellenangabe
  • 8:11
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40035-019-0153-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446289/ |
1000 Ergänzendes Material
  • https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-019-0153-0#Decs |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (n = 296) and controls (n = 295) free of neuropsychiatric disease. Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment. METHODS: NMDA antibodies were analysed in the serum of patients and controls using well established validated assays. We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics. RESULTS: The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients (13%) than in controls (22%) and higher than in previous studies in both groups. NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment, nor with quantitative indicators of disease severity and cognitive impairment. A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients. CONCLUSION: It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g. to Parkinson disease with dementia, while NMDA IgG antibodies define a separate disease of its own.
1000 Sacherschließung
lokal NMDA antibody
lokal Parkinson disease
lokal NMDA IgA/IgM antibodies
lokal Cognitive impairment
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Christian-Albrechts-Universität zu Kiel |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Intramural funding of the Dept. of Neurology
1000 Dateien
  1. No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Christian-Albrechts-Universität zu Kiel |
    1000 Förderprogramm Intramural funding of the Dept. of Neurology
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415249.rdf
1000 Erstellt am 2019-07-17T13:40:58.855+0200
1000 Erstellt von 266
1000 beschreibt frl:6415249
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Nov 05 09:50:45 CET 2019
1000 Objekt bearb. Tue Nov 05 09:50:45 CET 2019
1000 Vgl. frl:6415249
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415249 |
1000 Sichtbarkeit Metadaten public
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