Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease

  1. Pesch, Beate
  2. Casjens, Swaantje
  3. Woitalla, Dirk
  4. Dharmadhikari, Shalmali
  5. Edmondson, David A.
  6. Zella, Maria Angela Samis
  7. Lehnert, Martin
  8. Lotz, Anne
  9. Herrmann, Lennard
  10. Muhlack, Siegfried
  11. Kraus, Peter
  12. Yeh, Chien-Lin
  13. Glaubitz, Benjamin
  14. Schmidt-Wilcke, Tobias
  15. Gold, Ralf
  16. van Thriel, Christoph ORCID logo
  17. BrĂĽning, Thomas
  18. Tönges, Lars ORCID logo
  19. Dydak, Ulrike ORCID logo

Download
cells-08-00096.pdf 926,69KB
WeightNameValue
1000 Titel
  • Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease
1000 Autor/in
  1. Pesch, Beate |
  2. Casjens, Swaantje |
  3. Woitalla, Dirk |
  4. Dharmadhikari, Shalmali |
  5. Edmondson, David A. |
  6. Zella, Maria Angela Samis |
  7. Lehnert, Martin |
  8. Lotz, Anne |
  9. Herrmann, Lennard |
  10. Muhlack, Siegfried |
  11. Kraus, Peter |
  12. Yeh, Chien-Lin |
  13. Glaubitz, Benjamin |
  14. Schmidt-Wilcke, Tobias |
  15. Gold, Ralf |
  16. van Thriel, Christoph |
  17. BrĂĽning, Thomas |
  18. Tönges, Lars |
  19. Dydak, Ulrike |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-29
1000 Erschienen in
1000 Quellenangabe
  • 8(2):96
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/cells8020096 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406520/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/2073-4409/8/2/96#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron and neurometabolites, which were analyzed along with other predictors of motor dysfunction in Parkinson’s disease (PD). Tapping hits, tremor amplitude, and the scores derived from part III of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS3 scores) were determined in 35 male PD patients and 35 controls. The iron-sensitive MRI relaxation rate R2* was measured in the globus pallidus and substantia nigra. Îł-aminobutyric acid (GABA)-edited and short echo-time MRS was used for the quantification of neurometabolites in the striatum and thalamus. Associations of R2*, neurometabolites, and other factors with motor function were estimated with Spearman correlations and mixed regression models to account for repeated measurements (hands, hemispheres). In PD patients, R2* and striatal GABA correlated with MDS-UPDRS3 scores if not adjusted for age. Patients with akinetic-rigid PD subtype (N = 19) presented with lower creatine and striatal glutamate and glutamine (Glx) but elevated thalamic GABA compared to controls or mixed PD subtype. In PD patients, Glx correlated with an impaired dexterity when adjusted for covariates. Elevated myo-inositol was associated with more tapping hits and lower MDS-UPDRS3 scores. Our neuroimaging study provides evidence that motor dysfunction in PD correlates with alterations in brain iron and neurometabolites.
1000 SacherschlieĂźung
lokal spectroscopy
lokal neurometabolites
lokal motor dysfunction
lokal magnetic resonance spectroscopy
lokal magnetic resonance imaging
lokal GABA
lokal brain iron
lokal Parkinson’s disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGVzY2gsIEJlYXRl|https://frl.publisso.de/adhoc/uri/Q2FzamVucywgU3dhYW50amU=|https://frl.publisso.de/adhoc/uri/V29pdGFsbGEsIERpcms=|https://frl.publisso.de/adhoc/uri/RGhhcm1hZGhpa2FyaSwgU2hhbG1hbGk=|https://frl.publisso.de/adhoc/uri/RWRtb25kc29uLCBEYXZpZCBBLg==|https://frl.publisso.de/adhoc/uri/WmVsbGEsIE1hcmlhIEFuZ2VsYSBTYW1pcw==|https://frl.publisso.de/adhoc/uri/TGVobmVydCwgTWFydGlu|https://frl.publisso.de/adhoc/uri/TG90eiwgQW5uZQ==|https://frl.publisso.de/adhoc/uri/SGVycm1hbm4sIExlbm5hcmQ=|https://frl.publisso.de/adhoc/uri/TXVobGFjaywgU2llZ2ZyaWVk|https://frl.publisso.de/adhoc/uri/S3JhdXMsIFBldGVy|https://frl.publisso.de/adhoc/uri/WWVoLCBDaGllbi1MaW4=|https://frl.publisso.de/adhoc/uri/R2xhdWJpdHosIEJlbmphbWlu|https://frl.publisso.de/adhoc/uri/U2NobWlkdC1XaWxja2UsIFRvYmlhcw==|https://frl.publisso.de/adhoc/uri/R29sZCwgUmFsZg==|https://orcid.org/0000-0003-3215-9262|https://frl.publisso.de/adhoc/uri/QnLDvG5pbmcsIFRob21hcw==|https://orcid.org/0000-0001-6621-144X|https://orcid.org/0000-0003-1852-7110
1000 Label
1000 Förderer
  1. Employer’s Liability Insurance Association for Wood and Metals (Berufsgenossenschaft Holz und Metall) |
  2. National Institutes of Health |
1000 Fördernummer
  1. -
  2. R01ES020529
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Employer’s Liability Insurance Association for Wood and Metals (Berufsgenossenschaft Holz und Metall) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer R01ES020529
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415546.rdf
1000 Erstellt am 2019-08-01T13:15:55.552+0200
1000 Erstellt von 254
1000 beschreibt frl:6415546
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 22:33:00 CET 2020
1000 Objekt bearb. Mon Aug 12 08:35:24 CEST 2019
1000 Vgl. frl:6415546
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415546 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source