Download
1-s2.0-S1556086419300097-main.pdf 4,13MB
WeightNameValue
1000 Titel
  • Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC
1000 Autor/in
  1. Edlund, Karolina |
  2. Madjar, Katrin |
  3. Mattsson, Johanna S.M. |
  4. Djureinovic, Dijana |
  5. Lindskog, Cecilia |
  6. Brunnström, Hans |
  7. Koyi, Hirsh |
  8. Brandén, Eva |
  9. Jirström, Karin |
  10. Pontén, Fredrik |
  11. Rahnenführer, Jörg |
  12. Micke, Patrick |
  13. Hengstler, Jan |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-09
1000 Erschienen in
1000 Quellenangabe
  • 14(4):628-640
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.jtho.2018.12.022 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1556086419300097?via%3Dihub#appsec1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: Infiltration of T and B/plasma cells has been linked to NSCLC prognosis, but this has not been thoroughly investigated in relation to the expression of programmed death ligand 1 (PD-L1). Here, we determine the association of lymphocytes and PD-L1 with overall survival (OS) in two retrospective cohorts of operated NSCLC patients who were not treated with checkpoint inhibitors targeting the programmed death 1/PD-L1 axis. Moreover, we evaluate how PD-L1 positivity and clinicopathologic factors affect the prognostic association of lymphocytes. METHODS: Cluster of differentiation (CD) 3 (CD3)-, CD8-, CD4-, forkhead box P3 (FOXP3)-, CD20-, CD79A-, and immunoglobulin kappa constant (IGKC)-positive immune cells, and tumor PD-L1 positivity, were determined by immunohistochemistry on tissue microarrays (n = 705). Affymetrix data was analyzed for a patient subset, and supplemented with publicly available transcriptomics data (N = 1724). Associations with OS were assessed by Kaplan-Meier plots and uni- and multivariate Cox regression. RESULTS: Higher levels of T and B plasma cells were associated with longer OS (p = 0.004 and p < 0.001, for CD8 and IGKC, respectively). Highly proliferative tumors with few lymphocytes had the worst outcome. No association of PD-L1 positivity with OS was observed in a nonstratified patient population; however, a significant association with shorter OS was observed in never-smokers (p = 0.009 and p = 0.002, 5% and 50% cutoff). Lymphocyte infiltration was not associated with OS in PD-L1–positive tumors (50% cutoff). The prognostic association of lymphocyte infiltration also depended on the patients’ smoking history and histologic subtype. CONCLUSIONS: Proliferation, PD-L1 status, smoking history, and histology should be considered if lymphocyte infiltration is to be used as a prognostic biomarker.
1000 Sacherschließung
lokal squamous cell carcinoma
lokal adenocarcinoma
lokal lymphocyte
lokal prognosis
lokal Ki67
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-0276-2143|https://frl.publisso.de/adhoc/uri/IE1hZGphciwgS2F0cmlu|https://frl.publisso.de/adhoc/uri/TWF0dHNzb24sIEpvaGFubmEgUy5NLg==|https://frl.publisso.de/adhoc/uri/RGp1cmVpbm92aWMsIERpamFuYQ==|https://frl.publisso.de/adhoc/uri/TGluZHNrb2csIENlY2lsaWE=|https://frl.publisso.de/adhoc/uri/QnJ1bm5zdHLDtm0sIEhhbnM=|https://frl.publisso.de/adhoc/uri/S295aSwgSGlyc2g=|https://frl.publisso.de/adhoc/uri/QnJhbmTDqW4sIEV2YQ==|https://frl.publisso.de/adhoc/uri/Smlyc3Ryw7ZtLCBLYXJpbg==|https://frl.publisso.de/adhoc/uri/UG9udMOpbiwgRnJlZHJpaw==|https://frl.publisso.de/adhoc/uri/UmFobmVuZsO8aHJlciwgSsO2cmc=|https://frl.publisso.de/adhoc/uri/TWlja2UsIFBhdHJpY2s=|https://orcid.org/0000-0002-1427-5246
1000 Label
1000 Förderer
  1. Cancerfonden |
1000 Fördernummer
  1. 15 0831
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Cancerfonden |
    1000 Förderprogramm -
    1000 Fördernummer 15 0831
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415580.rdf
1000 Erstellt am 2019-08-02T09:49:05.309+0200
1000 Erstellt von 254
1000 beschreibt frl:6415580
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Mon Aug 12 10:42:45 CEST 2019
1000 Objekt bearb. Mon Aug 12 10:38:17 CEST 2019
1000 Vgl. frl:6415580
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415580 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source