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1000 Titel
  • Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations
1000 Autor/in
  1. Maltais-Payette, Ina |
  2. Boulet, Marie-Michèle |
  3. Prehn, Cornelia |
  4. Adamski, Jerzy |
  5. Tchernof, Andre |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-11-06
1000 Erschienen in
1000 Quellenangabe
  • 15:78
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12986-018-0316-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219091/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Visceral adipose tissue (VAT) area is a strong predictor of obesity-related cardiometabolic alterations, but its measurement is costly, time consuming and, in some cases, involves radiation exposure. Glutamate, a by-product of branched-chain-amino-acid (BCAA) catabolism, has been shown to be increased in visceral obese individuals. In this follow-up data analysis, we aimed to investigate the ability of plasma glutamate to identify individuals with visceral obesity and concomitant metabolic alterations. METHODS: Measurements of adiposity, targeted blood metabolomics and cardiometabolic risk factors were performed in 59 healthy middle-aged women. Visceral and subcutaneous adipose tissue areas were measured by computed tomography (CT) whereas body fat and lean mass were assessed by dual-energy x-ray absorptiometry (DEXA). RESULTS: The univariate Pearson correlation coefficient between glutamate and VAT area was r = 0.46 (p < 0.001) and it was r = 0.36 (p = 0.006) when adjusted for total body fat mass. Glutamate allowed to identify individuals with VAT areas ≥100 cm2 (ROC_AUC: 0.78, 95% CI: 0.66–0.91) and VAT ≥130 cm2 (ROC_AUC: 0.71, 95% CI: 0.56–0.87). The optimal glutamate concentration threshold determined from the ROC curve (glutamate ≥34.6 μmol/L) had a greater sensitivity than the metabolic syndrome (MetS) and the hypertriglyceridemic waist (HTW) phenotype to identify individuals with VAT ≥100 cm2 (83% for glutamate vs 52% for the MetS and 35% for the HTW). Variance analysis showed that women with a high circulating glutamate level (≥34.6 μmol/L) had an altered metabolic profile, particularly regarding total triglyceride levels and the amount of triglycerides and cholesterol in very-low-density lipoproteins (all p < 0.01). CONCLUSION: Circulating glutamate is strongly associated with VAT area and may represent a potential screening tool for visceral obesity and alterations of the metabolic profile.
1000 Sacherschließung
lokal Glutamate
lokal Branched-chain amino acids
lokal Metabolomics
lokal Waist circumference
lokal Visceral obesity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFsdGFpcy1QYXlldHRlLCBJbmE=|https://frl.publisso.de/adhoc/uri/Qm91bGV0LCBNYXJpZS1NaWNow6hsZQ==|https://frl.publisso.de/adhoc/uri/UHJlaG4sIENvcm5lbGlhIA==|https://frl.publisso.de/adhoc/uri/QWRhbXNraSwgSmVyenk=|https://orcid.org/0000-0002-2587-1000
1000 Label
1000 Förderer
  1. Canadian Institutes of Health Research |
  2. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6417269.rdf
1000 Erstellt am 2019-11-05T15:53:20.783+0100
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1000 Zuletzt bearbeitet Thu Jan 30 17:38:34 CET 2020
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1000 Oai Id
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