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WeightNameValue
1000 Titel
  • DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus
1000 Autor/in
  1. Zhou, Zheng |
  2. Sun, Bao |
  3. Li, Xiaoping |
  4. Zhu, Chunsheng |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-06-28
1000 Erschienen in
1000 Quellenangabe
  • 15:47
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12986-018-0283-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025823/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic β cells and the body’s resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease.
1000 Sacherschließung
lokal T2DM
lokal Insulin resistance
lokal DNA methylation
lokal Insulin-sensitive organs
lokal Insulin secretion
1000 Fächerklassifikation (DDC)
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