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1000 Titel
  • Risk-adapted Treatment Strategy For COVID-19 Patients
1000 Autor/in
  1. Zheng, Changcheng |
  2. Wang, Jinquan |
  3. Guo, Hui |
  4. Lu, Zhaohui |
  5. Ma, Yan |
  6. Zhu, Yuyou |
  7. Xia, Daqing |
  8. Wang, Yinzhong |
  9. He, Hongliang |
  10. Zhou, Jian |
  11. Wang, Yong |
  12. Fei, Mingming |
  13. Yin, Yihong |
  14. Zheng, Mao |
  15. Xu, Yehong |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-27
1000 Erschienen in
1000 Quellenangabe
  • 94:74-77
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.ijid.2020.03.047 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: There are no clear expert consensus or guidelines on how to treat 2019 coronavirus disease (COVID-19). The objective of this study is to investigate the short-term effect of risk-adapted treatment strategy on patients with COVID-19. METHODS: We collected the medical records of 55 COVID-19 patients for analysis. We divided these patients into mild, moderate and severe groups, and risk-adapted treatment approaches were given according to the illness severity. RESULTS: Twelve patients were in mild group and 22 were in moderate group (non-severe group, n=34), and 21 patients were in severe group. At the end of the first two weeks after admission, clinical manifestations had completely despeared in 31(91.2%)patients in non-severe group, and 18(85.7%) patients in severe group (p=0.85). Both groups had a satisfied chest CT imaging recovery, which includes 22(64.7%) patients in non-severe group and 12(57.1%) patients in severe group recovered at least 50% of the whole leisions in the first week, and 28(82.4%) and 16(76.2%) recovered at least 75% in the second week, respectively. There were no significant differences in SARS-CoV-2 RNA clearance between two group (p=0.92). There were also no significant differences in the levels of SARS-CoV-2-IgM and IgG antibody production between the two groups (p=0.13, 0.62). There were 45 cases were discharged from the hospital, and no patients died at the time of this clinical analysis. CONCLUSIONS: Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. In severe COVID-19 patients, early and short-term use of low-dose methylprednisolone was beneficial and did not delay SARS-CoV-2 RNA clearance and influence IgG antibody production.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal antiviral treatment
lokal risk-adapted treatment strategy
lokal novel coronavirus pneumonia
lokal low-dose corticosteroid
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Dateien
  1. Risk-adapted Treatment Strategy For COVID-19 Patients
1000 Objektart article
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1000 @id frl:6419990.rdf
1000 Erstellt am 2020-04-14T09:36:21.912+0200
1000 Erstellt von 122
1000 beschreibt frl:6419990
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2021-09-14T19:50:18.176+0200
1000 Objekt bearb. Tue Sep 14 19:50:17 CEST 2021
1000 Vgl. frl:6419990
1000 Oai Id
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