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1000 Titel
  • Kidney disease is associated with in-hospital death of patients with COVID-19
1000 Autor/in
  1. Cheng, Yichun |
  2. Luo, Ran |
  3. Wang, Kun |
  4. Zhang, Meng |
  5. Wang, Zhixiang |
  6. Dong, Lei |
  7. Li, Junhua |
  8. Yao, Ying |
  9. Ge, Shuwang |
  10. Xu, Gang |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-20
1000 Erschienen in
1000 Quellenangabe
  • In Press
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.kint.2020.03.005 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110296/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In December 2019, a coronavirus 2019 (COVID-19) disease outbreak occurred in Wuhan, Hubei Province, China, and rapidly spread to other areas worldwide. Although diffuse alveolar damage and acute respiratory failure were the main features, the involvement of other organs needs to be explored. Since information on kidney disease in patients with COVID-19 is limited, we determined the prevalence of acute kidney injury (AKI) in patients with COVID-19. Further, we evaluated the association between markers of abnormal kidney function and death in patients with COVID-19. This was a prospective cohort study of 701 patients with COVID-19 admitted in a tertiary teaching hospital that also encompassed three affiliates following this major outbreak in Wuhan in 2020 of whom 113 (16.1%) died in hospital. Median age of the patients was 63 years (interquartile range, 50-71), including 367 men and 334 women. On admission, 43.9% of patients had proteinuria and 26.7% had hematuria. The prevalence of elevated serum creatinine, elevated blood urea nitrogen and estimated glomerular filtration under 60 ml/min/1.73m2 were 14.4, 13.1 and 13.1%, respectively. During the study period, AKI occurred in 5.1% patients. Kaplan-Meier analysis demonstrated that patients with kidney disease had a significantly higher risk for in-hospital death. Cox proportional hazard regression confirmed that elevated baseline serum creatinine (hazard ratio: 2.10, 95% confidence interval: 1.36-3.26), elevated baseline blood urea nitrogen (3.97, 2.57-6.14), AKI stage 1 (1.90, 0.76-4.76), stage 2 (3.51, 1.49-8.26), stage 3 (4.38, 2.31-8.31), proteinuria 1+ (1.80, 0.81-4.00), 2+∼3+ (4.84, 2.00-11.70), and hematuria 1+ (2.99, 1.39-6.42), 2+∼3+ (5.56,2.58- 12.01) were independent risk factors for in-hospital death after adjusting for age, sex, disease severity, comorbidity and leukocyte count. Thus, our findings show the prevalence of kidney disease on admission and the development of AKI during hospitalization in patients with COVID-19 is high and is associated with in-hospital mortality. Hence, clinicians should increase their awareness of kidney disease in patients with severe COVID-19.
1000 Sacherschließung
lokal acute kidney injury
gnd 1206347392 COVID-19
lokal kidney disease
lokal Pneumonia
lokal in-hospital death
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Q2hlbmcsIFlpY2h1bg==|https://frl.publisso.de/adhoc/uri/THVvLCBSYW4=|https://frl.publisso.de/adhoc/uri/V2FuZywgS3Vu|https://frl.publisso.de/adhoc/uri/WmhhbmcsIE1lbmc=|https://frl.publisso.de/adhoc/uri/V2FuZywgWmhpeGlhbmc=|https://frl.publisso.de/adhoc/uri/RG9uZywgTGVp|https://frl.publisso.de/adhoc/uri/TGksIEp1bmh1YQ==|https://frl.publisso.de/adhoc/uri/WWFvLCBZaW5n|https://frl.publisso.de/adhoc/uri/R2UsIFNodXdhbmc=|https://frl.publisso.de/adhoc/uri/WHUsIEdhbmc=
1000 Label
1000 Förderer
  1. National Natural Science Foundation of China |
  2. Deutsche Forschungsgemeinschaft |
  3. Ministry of Science and Technology of the People's Republic of China |
1000 Fördernummer
  1. 81761138041; 81570667; 81470948; 81670633; 91742204
  2. 81761138041
  3. 2018YFC1314003-1; 2015BAI12B07; 2016YFC0906103
1000 Förderprogramm
  1. International (Regional) Cooperation and Exchange Projects; Major Research Plan
  2. International (Regional) Cooperation and Exchange Projects
  3. National Key Research and Development Program
1000 Dateien
  1. Kidney disease is associated with in-hospital death of patients with COVID-19
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm International (Regional) Cooperation and Exchange Projects; Major Research Plan
    1000 Fördernummer 81761138041; 81570667; 81470948; 81670633; 91742204
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm International (Regional) Cooperation and Exchange Projects
    1000 Fördernummer 81761138041
  3. 1000 joinedFunding-child
    1000 Förderer Ministry of Science and Technology of the People's Republic of China |
    1000 Förderprogramm National Key Research and Development Program
    1000 Fördernummer 2018YFC1314003-1; 2015BAI12B07; 2016YFC0906103
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6420102.rdf
1000 Erstellt am 2020-04-15T14:16:45.573+0200
1000 Erstellt von 122
1000 beschreibt frl:6420102
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon May 30 13:41:04 CEST 2022
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1000 Vgl. frl:6420102
1000 Oai Id
  1. oai:frl.publisso.de:frl:6420102 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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