Download
1471-2172-10-35.pdf 737,69KB
WeightNameValue
1000 Titel
  • Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
1000 Autor/in
  1. Law, Helen KW |
  2. Cheung, Chung Yan |
  3. Sia, Sin Fun |
  4. Chan, Yuk On |
  5. Peiris, JS Malik |
  6. Lau, Yu Lung |
1000 Erscheinungsjahr 2009
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-06-08
1000 Erschienen in
1000 Quellenangabe
  • 10(1):35
1000 Copyrightjahr
  • 2009
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/1471-2172-10-35 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700820/ |
1000 Ergänzendes Material
  • https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-10-35#Sec15 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The SARS outbreak in 2003 provides a unique opportunity for the study of human responses to a novel virus. We have previously reported that dendritic cells (DCs) might be involved in the immune escape mechanisms for SARS-CoV. In this study, we focussed on the gene expression of toll-like receptors (TLRs), chemokine receptors (CCRs) and death receptor ligands in SARS-CoV infected DCs. We also compared adult and cord blood (CB) DCs to find a possible explanation for the age-dependent severity of SARS. RESULTS: Our results demonstrates that SARS-CoV did not modulate TLR-1 to TLR-10 gene expression but significantly induced the expression of CCR-1, CCR-3, and CCR-5. There was also strong induction of TNF-related apoptosis-inducing ligand (TRAIL), but not Fas ligand gene expression in SARS-CoV infected DCs. Interestingly, the expressions of most genes studied were higher in CB DCs than adult DCs. CONCLUSION: The upregulation of chemokines and CCRs may facilitate DC migration from the infection site to the lymph nodes, whereas the increase of TRAIL may induce lymphocyte apoptosis. These findings may explain the increased lung infiltrations and lymphoid depletion in SARS patients. Further explorations of the biological significance of these findings are warranted.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Death Receptor Ligand
lokal Trail Expression
lokal Mouse Hepatitis Virus
lokal Post Infection
lokal TLRs Expression
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TGF3LCBIZWxlbiBLVw==|https://frl.publisso.de/adhoc/uri/Q2hldW5nLCBDaHVuZyBZYW4=|https://frl.publisso.de/adhoc/uri/U2lhLCBTaW4gRnVu|https://frl.publisso.de/adhoc/uri/Q2hhbiwgWXVrIE9u|https://frl.publisso.de/adhoc/uri/UGVpcmlzLCBKUyBNYWxpaw==|https://frl.publisso.de/adhoc/uri/TGF1LCBZdSBMdW5n
1000 Label
1000 Förderer
  1. University of Hong Kong |
  2. National Institute of Allergy and Infectious Diseases |
  3. Food and Health Bureau |
1000 Fördernummer
  1. -
  2. AI 95357
  3. RFCID 03040772
1000 Förderprogramm
  1. Special SARS Research Fund; Outstanding Researcher Award
  2. Public Health Research
  3. Control of Infectious Diseases
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer University of Hong Kong |
    1000 Förderprogramm Special SARS Research Fund; Outstanding Researcher Award
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer National Institute of Allergy and Infectious Diseases |
    1000 Förderprogramm Public Health Research
    1000 Fördernummer AI 95357
  3. 1000 joinedFunding-child
    1000 Förderer Food and Health Bureau |
    1000 Förderprogramm Control of Infectious Diseases
    1000 Fördernummer RFCID 03040772
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6420403.rdf
1000 Erstellt am 2020-04-23T14:39:25.321+0200
1000 Erstellt von 122
1000 beschreibt frl:6420403
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Apr 23 14:40:33 CEST 2020
1000 Objekt bearb. Thu Apr 23 14:40:15 CEST 2020
1000 Vgl. frl:6420403
1000 Oai Id
  1. oai:frl.publisso.de:frl:6420403 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source