The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS

  1. Schob, Stefan
  2. Schicht, Martin
  3. Sel, Saadettin
  4. Stiller, Dankwart
  5. Kekulé, Alexander ORCID logo
  6. Paulsen, Friedrich
  7. Maronde, Erik
  8. Bräuer, Lars

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WeightNameValue
1000 Titel
  • The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS
1000 Autor/in
  1. Schob, Stefan |
  2. Schicht, Martin |
  3. Sel, Saadettin |
  4. Stiller, Dankwart |
  5. Kekulé, Alexander |
  6. Paulsen, Friedrich |
  7. Maronde, Erik |
  8. Bräuer, Lars |
1000 Erscheinungsjahr 2013
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-09-30
1000 Erschienen in
1000 Quellenangabe
  • 8(9):e74412
1000 Copyrightjahr
  • 2013
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0074412 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787032/ |
1000 Ergänzendes Material
  • https://doi.org/10.1371/annotation/920eb90c-4f7f-4468-ae9c-1198b7b952fc |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system. The ability of surfactant protein A and surfactant protein D to bind various pathogens and facilitate their elimination has been described in a vast number of studies. Surfactant proteins are very important in modulating the host's inflammatory response and participate in the clearance of apoptotic cells. Surfactant protein B and surfactant protein C are proteins responsible for lowering the surface tension in the lungs. The aim of this study was an investigation of expression of surfactant proteins in the central nervous system to assess their specific distribution patterns. The second aim was to quantify surfactant proteins in cerebrospinal fluid of healthy subjects compared to patients suffering from different neuropathologies. The expression of mRNA for the surfactant proteins was analyzed with RT-PCR done with samples from different parts of the human brain. The production of the surfactant proteins in the brain was verified using immunohistochemistry and Western blot. The concentrations of the surfactant proteins in cerebrospinal fluid from healthy subjects and patients suffering from neuropathologic conditions were quantified using ELISA. Our results revealed that surfactant proteins are present in the central nervous system and that the concentrations of one or more surfactant proteins in healthy subjects differed significantly from those of patients affected by central autoimmune processes, CNS infections or cerebral infarction. Based on the localization of the surfactant proteins in the brain, their different levels in normal versus pathologic samples of cerebrospinal fluid and their well-known functions in the lungs, it appears that the surfactant proteins may play roles in host defense of the brain, facilitation of cerebrospinal fluid secretion and maintenance of the latter's rheological properties.
1000 Sacherschließung
lokal Choroid plexus
lokal Immunohistochemistry techniques
lokal Enzyme-linked immunoassays
lokal Central nervous system
lokal Cerebrospinal fluid
lokal Polymerase chain reaction
lokal Surfactants
lokal Infarction
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Nob2IsIFN0ZWZhbg==|https://frl.publisso.de/adhoc/uri/U2NoaWNodCwgTWFydGlu|https://frl.publisso.de/adhoc/uri/U2VsLCBTYWFkZXR0aW4=|https://frl.publisso.de/adhoc/uri/U3RpbGxlciwgRGFua3dhcnQ=|https://orcid.org/0000-0003-3511-8255|https://frl.publisso.de/adhoc/uri/UGF1bHNlbiwgRnJpZWRyaWNo|https://frl.publisso.de/adhoc/uri/TWFyb25kZSwgRXJpaw==|https://frl.publisso.de/adhoc/uri/QnLDpHVlciwgTGFycw==
1000 Hinweis
  • Correction, 12 Nov 2013: Schob S, Schicht M, Sel S, Stiller D, Kekulé AS, et al. (2013) Correction: The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS. PLOS ONE 8(11): 10.1371/annotation/920eb90c-4f7f-4468-ae9c-1198b7b952fc.
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Martin-Luther-Universität Halle-Wittenberg |
1000 Fördernummer
  1. 1329/12-1; 3681/2-1
  2. -
1000 Förderprogramm
  1. -
  2. Wilhelm Roux Program
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer 1329/12-1; 3681/2-1
  2. 1000 joinedFunding-child
    1000 Förderer Martin-Luther-Universität Halle-Wittenberg |
    1000 Förderprogramm Wilhelm Roux Program
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6421147.rdf
1000 Erstellt am 2020-06-02T10:16:50.046+0200
1000 Erstellt von 25
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1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2020-06-02T10:18:55.394+0200
1000 Objekt bearb. Tue Jun 02 10:18:42 CEST 2020
1000 Vgl. frl:6421147
1000 Oai Id
  1. oai:frl.publisso.de:frl:6421147 |
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