Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

  1. Zumel-Marne, Angela
  2. Kundi, Michael
  3. Castaño-Vinyals, Gemma
  4. Alguacil, Juan
  5. Petridou, Eleni
  6. Georgakis, Marios K.
  7. Suárez-Varela, Maria M.
  8. Sadetzki, Siegal
  9. Piro, Sara
  10. Nagrani, Rajini ORCID logo
  11. Filippini, Graziella
  12. Hutter, Hans-Peter
  13. Dikshit, Rajesh
  14. Woehrer, Adelheid
  15. Maule, Milena
  16. Weinmann, Tobias
  17. Krewski, Daniel
  18. 't Mannetje, Andrea
  19. Momoli, Franco
  20. Lacour, Brigitte
  21. Mattioli, Stefano
  22. Spinelli, John
  23. Ritvo, Paul
  24. Remen, Thomas
  25. Kojimahara, Noriko
  26. Eng, Amanda
  27. Thurston, Angela
  28. Lim, Hyung-ryul
  29. Ha, Mina
  30. Yamaguchi, Naohito
  31. Mohipp, Charmaine
  32. Bouka, Evdoxia
  33. Eastman, Chelsea
  34. Vermeulen, Roel
  35. Kromhout, Hans
  36. Cardis, Elisabeth

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Zumel-Marne-et-al_2020_Clinical presentation of young people (10–24 years old) with brain tumors_Results from the international MOBI-Kids study.pdf 792,30KB
WeightNameValue
1000 Titel
  • Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study
1000 Autor/in
  1. Zumel-Marne, Angela |
  2. Kundi, Michael |
  3. Castaño-Vinyals, Gemma |
  4. Alguacil, Juan |
  5. Petridou, Eleni |
  6. Georgakis, Marios K. |
  7. Suárez-Varela, Maria M. |
  8. Sadetzki, Siegal |
  9. Piro, Sara |
  10. Nagrani, Rajini |
  11. Filippini, Graziella |
  12. Hutter, Hans-Peter |
  13. Dikshit, Rajesh |
  14. Woehrer, Adelheid |
  15. Maule, Milena |
  16. Weinmann, Tobias |
  17. Krewski, Daniel |
  18. 't Mannetje, Andrea |
  19. Momoli, Franco |
  20. Lacour, Brigitte |
  21. Mattioli, Stefano |
  22. Spinelli, John |
  23. Ritvo, Paul |
  24. Remen, Thomas |
  25. Kojimahara, Noriko |
  26. Eng, Amanda |
  27. Thurston, Angela |
  28. Lim, Hyung-ryul |
  29. Ha, Mina |
  30. Yamaguchi, Naohito |
  31. Mohipp, Charmaine |
  32. Bouka, Evdoxia |
  33. Eastman, Chelsea |
  34. Vermeulen, Roel |
  35. Kromhout, Hans |
  36. Cardis, Elisabeth |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-03
1000 Erschienen in
1000 Quellenangabe
  • 147:427-440
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11060-020-03437-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136306/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s11060-020-03437-4#Sec9 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53–4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
1000 Sacherschließung
lokal Brain tumor
lokal Diagnosis
lokal Clinical characteristic
lokal Symptom
lokal Central nervous system tumor
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/WnVtZWwtTWFybmUsIEFuZ2VsYQ==|https://frl.publisso.de/adhoc/uri/S3VuZGksIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/Q2FzdGHDsW8tVmlueWFscywgR2VtbWE=|https://frl.publisso.de/adhoc/uri/QWxndWFjaWwsIEp1YW4=|https://frl.publisso.de/adhoc/uri/UGV0cmlkb3UsIEVsZW5p|https://frl.publisso.de/adhoc/uri/R2Vvcmdha2lzLCBNYXJpb3MgSy4=|https://frl.publisso.de/adhoc/uri/U3XDoXJlei1WYXJlbGEsIE1hcmlhIE0u|https://frl.publisso.de/adhoc/uri/U2FkZXR6a2ksIFNpZWdhbA==|https://frl.publisso.de/adhoc/uri/UGlybywgU2FyYQ==|https://orcid.org/0000-0002-1708-2319|https://frl.publisso.de/adhoc/uri/RmlsaXBwaW5pLCBHcmF6aWVsbGE=|https://frl.publisso.de/adhoc/uri/SHV0dGVyLCBIYW5zLVBldGVy|https://frl.publisso.de/adhoc/uri/RGlrc2hpdCwgUmFqZXNo|https://frl.publisso.de/adhoc/uri/V29laHJlciwgQWRlbGhlaWQ=|https://frl.publisso.de/adhoc/uri/TWF1bGUsIE1pbGVuYQ==|https://frl.publisso.de/adhoc/uri/V2Vpbm1hbm4sIFRvYmlhcw==|https://frl.publisso.de/adhoc/uri/S3Jld3NraSwgRGFuaWVs|https://frl.publisso.de/adhoc/uri/J3QgTWFubmV0amUsIEFuZHJlYQ==|https://frl.publisso.de/adhoc/uri/TW9tb2xpLCBGcmFuY28=|https://frl.publisso.de/adhoc/uri/TGFjb3VyLCBCcmlnaXR0ZQ==|https://frl.publisso.de/adhoc/uri/TWF0dGlvbGksIFN0ZWZhbm8=|https://frl.publisso.de/adhoc/uri/U3BpbmVsbGksIEpvaG4=|https://frl.publisso.de/adhoc/uri/Uml0dm8sIFBhdWw=|https://frl.publisso.de/adhoc/uri/UmVtZW4sIFRob21hcw==|https://frl.publisso.de/adhoc/uri/S29qaW1haGFyYSwgTm9yaWtv|https://frl.publisso.de/adhoc/uri/RW5nLCBBbWFuZGE=|https://frl.publisso.de/adhoc/uri/VGh1cnN0b24sIEFuZ2VsYQ==|https://frl.publisso.de/adhoc/uri/TGltLCBIeXVuZy1yeXVs|https://frl.publisso.de/adhoc/uri/SGEsIE1pbmE=|https://frl.publisso.de/adhoc/uri/WWFtYWd1Y2hpLCBOYW9oaXRv|https://frl.publisso.de/adhoc/uri/TW9oaXBwLCBDaGFybWFpbmU=|https://frl.publisso.de/adhoc/uri/Qm91a2EsIEV2ZG94aWE=|https://frl.publisso.de/adhoc/uri/RWFzdG1hbiwgQ2hlbHNlYQ==|https://frl.publisso.de/adhoc/uri/VmVybWV1bGVuLCBSb2Vs|https://frl.publisso.de/adhoc/uri/S3JvbWhvdXQsIEhhbnM=|https://frl.publisso.de/adhoc/uri/Q2FyZGlzLCBFbGlzYWJldGg=
1000 Label
1000 Förderer
  1. Seventh Framework Programme |
  2. Ministerio de Ciencia e Innovación |
  3. Instituto de Salud Carlos III |
  4. Ministero della Salute |
  5. Canadian Institutes of Health Research |
  6. Canadian Wireless Telecommunications Association (CWTA) |
  7. Bundesamt für Strahlenschutz |
  8. Ministry of Internal Affairs and Communications |
  9. Health Research Council of New Zealand |
  10. Cure Kids |
  11. Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail |
  12. Institut National Du Cancer |
  13. Pfizer Foundation |
  14. Ligue Contre le Cancer |
  15. Board of Research in Nuclear Sciences |
1000 Fördernummer
  1. 226873; 603794
  2. -
  3. -
  4. RF-2009-1546284
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. FSRF2008-3
  12. -
  13. -
  14. -
  15. -
1000 Förderprogramm
  1. MOBI-KIDS; GERONIMO
  2. -
  3. Spanish Health Research Fund (FIS)
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
  13. -
  14. -
  15. -
1000 Dateien
  1. Clinical presentation of young people (10–24 years old) with brain tumors: Results from the international MOBI-Kids study
    Clinical presentation of young people (10–24 years old) with brain tumors: Results from the international MOBI-Kids study
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm MOBI-KIDS; GERONIMO
    1000 Fördernummer 226873; 603794
  2. 1000 joinedFunding-child
    1000 Förderer Ministerio de Ciencia e Innovación |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Instituto de Salud Carlos III |
    1000 Förderprogramm Spanish Health Research Fund (FIS)
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Ministero della Salute |
    1000 Förderprogramm -
    1000 Fördernummer RF-2009-1546284
  5. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Canadian Wireless Telecommunications Association (CWTA) |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer Bundesamt für Strahlenschutz |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer Ministry of Internal Affairs and Communications |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer Health Research Council of New Zealand |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Cure Kids |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail |
    1000 Förderprogramm -
    1000 Fördernummer FSRF2008-3
  12. 1000 joinedFunding-child
    1000 Förderer Institut National Du Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  13. 1000 joinedFunding-child
    1000 Förderer Pfizer Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  14. 1000 joinedFunding-child
    1000 Förderer Ligue Contre le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer Board of Research in Nuclear Sciences |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6421810.rdf
1000 Erstellt am 2020-07-13T12:09:53.161+0200
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