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Thumann-et-al_2020_Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity.pdf 1,48MB
WeightNameValue
1000 Titel
  • Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity
1000 Autor/in
  1. Thumann, Barbara |
  2. Michels, Nathalie |
  3. Felső, Regina |
  4. Hunsberger, Monica |
  5. Kaprio, Jaakko |
  6. Moreno, Luis A. |
  7. Siani, Alfonso |
  8. Tornaritis, Michael |
  9. Veidebaum, Toomas |
  10. De Henauw, Stefaan |
  11. Ahrens, Wolfgang |
  12. Börnhorst, Claudia |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
  2. The I.Family consortium |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-30
1000 Erschienen in
1000 Quellenangabe
  • 15(6):e0235049
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0235049 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326225/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235049#sec017 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Short sleep duration has been suggested to lead to insulin resistance both directly by altering glucose metabolism and indirectly through obesity. This study aims to investigate associations between nocturnal sleep duration and insulin resistance considering abdominal obesity as a mediator. METHODS: We analysed data of 3 900 children aged 2–15 years participating in the second (2009/10) and third (2013/14) examination wave of the European IDEFICS/I.Family study (hereafter referred to as baseline and follow-up). Information on nocturnal sleep duration was collected by questionnaires and age-standardised (SLEEP z-score). The homeostasis model assessment (HOMA) was calculated from fasting insulin and fasting glucose obtained from blood samples; waist circumference (WAIST) was measured with an inelastic tape. HOMA and WAIST were used as indicators for insulin resistance and abdominal obesity, respectively, and transformed to age- and sex-specific z-scores. Cross-sectional and longitudinal associations between SLEEP z-score and HOMA z-score were investigated based on a path model considering WAIST z-score as a mediator adjusting for relevant confounders. RESULTS: Cross-sectionally, baseline SLEEP z-score was negatively associated with baseline WAIST z-score (unstandardised effect estimate -0.120, 95% confidence interval [-0.167; -0.073]). We observed no direct effect of baseline SLEEP z-score on baseline HOMA z-score but a negative indirect effect through baseline WAIST z-score (-0.042 [-0.058; -0.025]). Longitudinally, there was no direct effect of baseline SLEEP z-score on HOMA z-score at follow-up but a negative indirect effect through both baseline WAIST z-score and WAIST z-score at follow-up (-0.028 [-0.040; -0.016]). CONCLUSIONS: Our results do not support the hypothesis of an association between short sleep duration and insulin resistance independent of abdominal obesity. However, longer sleep duration may exert short and long term beneficial effects on insulin resistance through its beneficial effects on abdominal obesity.
1000 Sacherschließung
lokal Obesity
lokal Adolescents
lokal Children
lokal Childhood obesity
lokal Insulin resistance
lokal Insulin
lokal Sleep
lokal Schools
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8145-5936|https://frl.publisso.de/adhoc/uri/TWljaGVscywgTmF0aGFsaWU=|https://frl.publisso.de/adhoc/uri/RmVsc8WRLCBSZWdpbmE=|https://frl.publisso.de/adhoc/uri/SHVuc2JlcmdlciwgTW9uaWNh|https://orcid.org/0000-0002-3716-2455|https://frl.publisso.de/adhoc/uri/TW9yZW5vLCBMdWlzIEEu|https://frl.publisso.de/adhoc/uri/U2lhbmksIEFsZm9uc28=|https://frl.publisso.de/adhoc/uri/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/uri/RGUgSGVuYXV3LCBTdGVmYWFu|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0001-9004-1540|https://frl.publisso.de/adhoc/uri/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==|https://frl.publisso.de/adhoc/uri/VGhlIEkuRmFtaWx5IGNvbnNvcnRpdW0=
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
  2. Seventh Framework Programme |
  3. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 266044
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. Open Access Fund
1000 Dateien
  1. Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 266044
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423063.rdf
1000 Erstellt am 2020-09-21T13:09:25.970+0200
1000 Erstellt von 266
1000 beschreibt frl:6423063
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed Sep 23 15:28:13 CEST 2020
1000 Objekt bearb. Mon Sep 21 13:10:23 CEST 2020
1000 Vgl. frl:6423063
1000 Oai Id
  1. oai:frl.publisso.de:frl:6423063 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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