Schink-et-al_2020_Estimating the Beginning of Pregnancy in German Claims Data_Development of an Algorithm With a Focus on the Expected Delivery Date.pdf 2,02MB
1000 Titel
  • Estimating the Beginning of Pregnancy in German Claims Data: Development of an Algorithm With a Focus on the Expected Delivery Date
1000 Autor/in
  1. Schink, Tania |
  2. Wentzell, Nadine |
  3. Dathe, Katarina |
  4. Onken, Marlies |
  5. Haug, Ulrike |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-08-12
1000 Erschienen in
1000 Quellenangabe
  • 8:350
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Estimating the beginning of pregnancy is crucial when studying drug safety in pregnancy, but important information in this regard, such as the last menstrual period (LMP), is generally not recorded in claims databases. The beginning of pregnancy is therefore usually estimated by subtracting a median length of pregnancy from the date of birth. Due to the variability in pregnancy lengths, this might result in non-negligible errors. German claims data may offer the possibility to estimate the beginning of pregnancy more precisely based on the expected delivery date (EDD) which can be coded once or more often during a pregnancy. PURPOSE: To estimate the beginning of pregnancy in German claims data focusing on the potential of the expected delivery date (EDD). METHODS: We included data of all pregnancies in women aged 12–50 years ending in a live birth between 2006 and 2015 identified in the German Pharmacoepidemiological Research Database (GePaRD). We assessed the number of coded EDDs per pregnancy and the concordance if ≥ 2 EDDs were coded. We estimated the beginning of pregnancy by subtracting 280 days from the EDD or the most frequent EDD (in case of discordant EDDs). To examine plausibility, we determined the distribution of pregnancy lengths and assessed whether the gestational age at which prenatal examinations were coded was plausible. For pregnancies without EDD, the beginning was estimated by subtracting the respective observed median lengths of pregnancy for preterm births, term births, and births after due date from the actual dates of birth. RESULTS: In 82.4% of pregnancies, at least one EDD was available (thereof 6.1% with only one EDD and 80.9% with ≥ 2 EDDs that were all concordant). The maximal difference between discordant EDDs was in median 5 days (interquartile range: 3–7 days). Based on the EDD, the median length of pregnancy was 276 days for term births and in 84.7% of pregnancies the second antibody screening test was performed in the recommended interval ± 2 weeks. In pregnancies without EDD the respective proportion was 84.9%. CONCLUSIONS: By using the EDD, the beginning of pregnancy can plausibly be estimated in German claims data.
1000 Sacherschließung
lokal Beginning of pregnancy
lokal Gestational age (GA)
lokal Electronic healthcare data
lokal Claims data
lokal Drug safety
lokal Duration of pregnancy
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. German Joint Federal Committee (G-BA) |
  2. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. AMTS in utero, 01VSF16010
  2. -
1000 Förderprogramm
  1. Innovation Fund
  2. Open Access Fund
1000 Dateien
  1. Estimating the Beginning of Pregnancy in German Claims Data:  Development of an Algorithm With a Focus on the Expected Delivery Date
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Joint Federal Committee (G-BA) |
    1000 Förderprogramm Innovation Fund
    1000 Fördernummer AMTS in utero, 01VSF16010
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423065.rdf
1000 Erstellt am 2020-09-21T13:53:02.102+0200
1000 Erstellt von 266
1000 beschreibt frl:6423065
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed Sep 23 15:31:53 CEST 2020
1000 Objekt bearb. Mon Sep 21 13:54:13 CEST 2020
1000 Vgl. frl:6423065
1000 Oai Id
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1000 Sichtbarkeit Metadaten public
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