Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

  1. Autrup, Herman
  2. Barile, Frank A.
  3. Berry, Sir Colin
  4. Blaauboer, Bas J.
  5. Boobis, Alan
  6. Bolt, Hermann M. ORCID logo
  7. Borgert, Christopher J.
  8. Dekant, Wolfgang
  9. Dietrich, Daniel
  10. Domingo, Jose L.
  11. Gori, Gio Batta
  12. Greim, Helmut
  13. Hengstler, Jan ORCID logo
  14. Kacew, Sam
  15. Marquardt, Hans
  16. Pelkonen, Olavi
  17. Savolainen, Kai
  18. Heslop-Harrison, Pat
  19. Vermeulen, Nico P.

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Autrup2020_Article_HumanExposureToSyntheticEndocr.pdf 560,12KB
WeightNameValue
1000 Titel
  • Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?
1000 Autor/in
  1. Autrup, Herman |
  2. Barile, Frank A. |
  3. Berry, Sir Colin |
  4. Blaauboer, Bas J. |
  5. Boobis, Alan |
  6. Bolt, Hermann M. |
  7. Borgert, Christopher J. |
  8. Dekant, Wolfgang |
  9. Dietrich, Daniel |
  10. Domingo, Jose L. |
  11. Gori, Gio Batta |
  12. Greim, Helmut |
  13. Hengstler, Jan |
  14. Kacew, Sam |
  15. Marquardt, Hans |
  16. Pelkonen, Olavi |
  17. Savolainen, Kai |
  18. Heslop-Harrison, Pat |
  19. Vermeulen, Nico P. |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-08
1000 Erschienen in
1000 Quellenangabe
  • 94:2549-2557
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-020-02800-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367909/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
1000 Sacherschließung
lokal Endocrine disruption
lokal Risk characterisation
lokal Testing
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