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CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans

  1. Martrus, Glòria ORCID logo
  2. Goebels, Hanna
  3. Langeneckert, Annika Elise ORCID logo
  4. Kah, Janine
  5. Flomm, Felix
  6. Ziegler, Annerose E.
  7. Niehrs, Annika ORCID logo
  8. Löbl, Sebastian M.
  9. Russu, Kristina
  10. Hess, Leonard U.
  11. Salzberger, Wilhelm
  12. Poch, Tobias
  13. Nashan, Björn
  14. Schramm, Christoph
  15. Oldhafer, Karl J.
  16. Dandri, Maura
  17. Koch, Martina
  18. Lunemann, Sebastian
  19. Altfeld, Marcus ORCID logo

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WeightNameValue
1000 Titel
  • CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans
1000 Autor/in
  1. Martrus, Glòria |
  2. Goebels, Hanna |
  3. Langeneckert, Annika Elise |
  4. Kah, Janine |
  5. Flomm, Felix |
  6. Ziegler, Annerose E. |
  7. Niehrs, Annika |
  8. Löbl, Sebastian M. |
  9. Russu, Kristina |
  10. Hess, Leonard U. |
  11. Salzberger, Wilhelm |
  12. Poch, Tobias |
  13. Nashan, Björn |
  14. Schramm, Christoph |
  15. Oldhafer, Karl J. |
  16. Dandri, Maura |
  17. Koch, Martina |
  18. Lunemann, Sebastian |
  19. Altfeld, Marcus |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-06-07
1000 Erschienen in
1000 Quellenangabe
  • 10:1247
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2019.01247 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568245/ |
1000 Ergänzendes Material
  • https://www.frontiersin.org/articles/10.3389/fimmu.2019.01247/full#h11 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Macrophages play central roles in inflammatory reactions and initiation of immune responses during infections. More than 80% of total tissue macrophages are described to be located in the liver as liver-resident macrophages, also named Kupffer cells (KCs). While studies in mice have established a central role of liver-resident KCs in regulating liver inflammation, their phenotype and function are not well-characterized in humans. Comparing paired human liver and peripheral blood samples, we observed significant differences in the distribution of macrophage (Mφ) subsets, with lower frequencies of CD14hiCD16lo and higher frequencies of CD14int−hiCD16int Mφ in human livers. Intrahepatic Mφ consisted of diverse subsets with differential expression of CD49a, a liver-residency marker previously described for human and mice NK cells, and VSIG4 and/or MARCO, two recently described human tissue Mφ markers. Furthermore, intrahepatic CD49a+ Mφ expressed significantly higher levels of maturation and activation markers, exhibited higher baseline levels of TNF-α, IL-12, and IL-10 production, but responded less to additional in vitro TLR stimulation. In contrast, intrahepatic CD49a− Mφ were highly responsive to stimulation with TLR ligands, similar to what was observed for CD49a− monocytes (MOs) in peripheral blood. Taken together, these studies identified populations of CD49a+, VSIG4+, and/or MARCO+ Mφ in human livers, and demonstrated that intrahepatic CD49a+ Mφ differed in phenotype and function from intrahepatic CD49a− Mφ as well as from peripheral blood-derived monocytes.
1000 Sacherschließung
lokal tissue residency
lokal cell activation
lokal monocytes/macrophages
lokal human liver
lokal CD49a
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-2879-3201|https://frl.publisso.de/adhoc/uri/R29lYmVscywgSGFubmE=|https://orcid.org/0000-0002-8234-1567|https://frl.publisso.de/adhoc/uri/S2FoLCBKYW5pbmU=|https://frl.publisso.de/adhoc/uri/RmxvbW0sIEZlbGl4|https://frl.publisso.de/adhoc/uri/WmllZ2xlciwgQW5uZXJvc2UgRS4=|https://orcid.org/0000-0002-2190-4346|https://frl.publisso.de/adhoc/uri/TMO2YmwsIFNlYmFzdGlhbiBNLg==|https://frl.publisso.de/adhoc/uri/UnVzc3UsIEtyaXN0aW5h|https://frl.publisso.de/adhoc/uri/SGVzcywgTGVvbmFyZCBVLg==|https://frl.publisso.de/adhoc/uri/U2FsemJlcmdlciwgV2lsaGVsbQ==|https://frl.publisso.de/adhoc/uri/UG9jaCwgVG9iaWFz|https://frl.publisso.de/adhoc/uri/TmFzaGFuLCBCasO2cm4g|https://frl.publisso.de/adhoc/uri/U2NocmFtbSwgQ2hyaXN0b3BoIA==|https://frl.publisso.de/adhoc/uri/T2xkaGFmZXIsIEthcmwgSi4g|https://frl.publisso.de/adhoc/uri/RGFuZHJpLCBNYXVyYSA=|https://frl.publisso.de/adhoc/uri/S29jaCwgTWFydGluYSA=|https://frl.publisso.de/adhoc/uri/THVuZW1hbm4sIFNlYmFzdGlhbiA=|https://orcid.org/0000-0001-5972-2997
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Helmut and Hannelore Greve Foundation |
  3. YAEL Foundation |
  4. Universitätsklinikum Hamburg-Eppendorf |
  5. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. SFB 841
  2. -
  3. -
  4. GRK SFB841; KFO306
  5. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SFB 841
  2. 1000 joinedFunding-child
    1000 Förderer Helmut and Hannelore Greve Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer YAEL Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Universitätsklinikum Hamburg-Eppendorf |
    1000 Förderprogramm -
    1000 Fördernummer GRK SFB841; KFO306
  5. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423493.rdf
1000 Erstellt am 2020-10-14T12:13:52.498+0200
1000 Erstellt von 24
1000 beschreibt frl:6423493
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Jun 02 07:11:53 CEST 2021
1000 Objekt bearb. Wed Jun 02 07:11:52 CEST 2021
1000 Vgl. frl:6423493
1000 Oai Id
  1. oai:frl.publisso.de:frl:6423493 |
1000 Sichtbarkeit Metadaten public
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