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1000 Titel
  • Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques
1000 Autor/in
  1. Sallet, Jerome |
  2. Noonan, MaryAnn |
  3. Thomas, Adam |
  4. O’Reilly, Jill X. |
  5. Anderson, Jesper |
  6. Papageorgiou, Georgios |
  7. Neubert, Franz X. |
  8. Ahmed, Bashir |
  9. Smith, Jackson |
  10. Bell, Andrew |
  11. Buckley, Mark |
  12. Roumazeilles, Lea |
  13. Cuell, Steven |
  14. Walton, Mark E. |
  15. Krug, Kristine |
  16. Mars, Rogier B. |
  17. Rushworth, Matthew |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-05-26
1000 Erschienen in
1000 Quellenangabe
  • 18(5):e3000605
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pbio.3000605 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274449/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000605#sec022 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • One of the most influential accounts of central orbitofrontal cortex-that it mediates behavioral flexibility-has been challenged by the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is unaffected when lesions are made by excitotoxin injection rather than aspiration. This suggests that the critical brain circuit mediating behavioral flexibility in reversal tasks lies beyond the central orbitofrontal cortex. To determine its identity, a group of nine macaques were taught discrimination reversal learning tasks, and its impact on gray matter was measured. Magnetic resonance imaging scans were taken before and after learning and compared with scans from two control groups, each comprising 10 animals. One control group learned discrimination tasks that were similar but lacked any reversal component, and the other control group engaged in no learning. Gray matter changes were prominent in posterior orbitofrontal cortex/anterior insula but were also found in three other frontal cortical regions: lateral orbitofrontal cortex (orbital part of area 12 [12o]), cingulate cortex, and lateral prefrontal cortex. In a second analysis, neural activity in posterior orbitofrontal cortex/anterior insula was measured at rest, and its pattern of coupling with the other frontal cortical regions was assessed. Activity coupling increased significantly in the reversal learning group in comparison with controls. In a final set of experiments, we used similar structural imaging procedures and analyses to demonstrate that aspiration lesion of central orbitofrontal cortex, of the type known to affect discrimination learning, affected structure and activity in the same frontal cortical circuit. The results identify a distributed frontal cortical circuit associated with behavioral flexibility.
1000 Sacherschließung
lokal Decision making
lokal Functional magnetic resonance imaging
lokal Macaque
lokal Animal performance
lokal Learning
lokal Central nervous system
lokal Magnetic resonance imaging
lokal Monkeys
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-7878-0209|https://orcid.org/0000-0002-1948-2471|https://orcid.org/0000-0002-2850-1419|https://frl.publisso.de/adhoc/uri/T_KAmVJlaWxseSwgSmlsbCBYLg==|https://frl.publisso.de/adhoc/uri/QW5kZXJzb24sIEplc3Blcg==|https://orcid.org/0000-0002-0121-3230|https://frl.publisso.de/adhoc/uri/TmV1YmVydCwgRnJhbnogWC4=|https://orcid.org/0000-0001-9989-2659|https://frl.publisso.de/adhoc/uri/U21pdGgsIEphY2tzb24=|https://orcid.org/0000-0001-8420-4622|https://orcid.org/0000-0001-7455-8486|https://orcid.org/0000-0003-2195-7621|https://orcid.org/0000-0002-8126-0060|https://frl.publisso.de/adhoc/uri/V2FsdG9uLCBNYXJrIEUu|https://orcid.org/0000-0001-7119-9350|https://frl.publisso.de/adhoc/uri/TWFycywgUm9naWVyIEIu|https://orcid.org/0000-0002-5578-9884
1000 Label
1000 Förderer
  1. Wellcome Trust |
  2. Academy of Medical Sciences |
  3. Biotechnology and Biological Sciences Research Council |
  4. Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
1000 Fördernummer
  1. 105651/Z/14/Z; 101092/Z/13/Z; 203139/Z/16/Z; SBF003\1143
  2. -
  3. BB/H016902/; BB/N019814/1
  4. 452-13-015
1000 Förderprogramm
  1. Henry Dale Fellowship; Strategic Award; Springboard fund
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm Henry Dale Fellowship; Strategic Award; Springboard fund
    1000 Fördernummer 105651/Z/14/Z; 101092/Z/13/Z; 203139/Z/16/Z; SBF003\1143
  2. 1000 joinedFunding-child
    1000 Förderer Academy of Medical Sciences |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Biotechnology and Biological Sciences Research Council |
    1000 Förderprogramm -
    1000 Fördernummer BB/H016902/; BB/N019814/1
  4. 1000 joinedFunding-child
    1000 Förderer Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
    1000 Förderprogramm -
    1000 Fördernummer 452-13-015
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423501.rdf
1000 Erstellt am 2020-10-14T14:42:35.749+0200
1000 Erstellt von 242
1000 beschreibt frl:6423501
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-10-19T08:26:28.633+0200
1000 Objekt bearb. Mon Oct 19 08:26:04 CEST 2020
1000 Vgl. frl:6423501
1000 Oai Id
  1. oai:frl.publisso.de:frl:6423501 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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