Age‐related rhesus macaque models of COVID‐19

  1. Yu, Pin
  2. Qi, Feifei
  3. Xu, Yanfeng
  4. Li, Fengdi
  5. Liu, Peipei
  6. Liu, Jiayi
  7. Bao, Linlin
  8. Deng, Wei
  9. Gao, Hong
  10. Xiang, Zhiguang
  11. Xiao, Chong
  12. Lv, Qi
  13. Gong, Shuran
  14. Liu, Jiangning
  15. Song, Zhiqi
  16. Qu, Yajin
  17. Xue, Jing
  18. Wei, Qiang
  19. Liu, Mingya
  20. Wang, Guanpeng
  21. Wang, Shunyi
  22. Yu, Haisheng
  23. Liu, Xing
  24. Huang, Baoying
  25. Wang, Wenling
  26. Zhao, Li
  27. Wang, Huijuan
  28. Ye, Fei
  29. Zhou, Weimin
  30. Zhen, Wei
  31. Han, Jun
  32. Wu, Guizhen
  33. Jin, Qi
  34. Wang, Jianwei
  35. Tan, Wenjie
  36. Qin, chuan ORCID logo

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WeightNameValue
1000 Titel
  • Age‐related rhesus macaque models of COVID‐19
1000 Autor/in
  1. Yu, Pin |
  2. Qi, Feifei |
  3. Xu, Yanfeng |
  4. Li, Fengdi |
  5. Liu, Peipei |
  6. Liu, Jiayi |
  7. Bao, Linlin |
  8. Deng, Wei |
  9. Gao, Hong |
  10. Xiang, Zhiguang |
  11. Xiao, Chong |
  12. Lv, Qi |
  13. Gong, Shuran |
  14. Liu, Jiangning |
  15. Song, Zhiqi |
  16. Qu, Yajin |
  17. Xue, Jing |
  18. Wei, Qiang |
  19. Liu, Mingya |
  20. Wang, Guanpeng |
  21. Wang, Shunyi |
  22. Yu, Haisheng |
  23. Liu, Xing |
  24. Huang, Baoying |
  25. Wang, Wenling |
  26. Zhao, Li |
  27. Wang, Huijuan |
  28. Ye, Fei |
  29. Zhou, Weimin |
  30. Zhen, Wei |
  31. Han, Jun |
  32. Wu, Guizhen |
  33. Jin, Qi |
  34. Wang, Jianwei |
  35. Tan, Wenjie |
  36. Qin, chuan |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-30
1000 Erschienen in
1000 Quellenangabe
  • 3(1):93-97
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/ame2.12108 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167234/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. METHODS: Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. RESULTS: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. CONCLUSION: SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal rhesus macaque model
lokal pneumonia
lokal pathogenicity
lokal SARS-CoV-2
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. National Basic Research Program of China (973 Program) |
  2. Chinese Academy of Medical Sciences |
  3. National Mega projects of China for Major Infectious Diseases |
1000 Fördernummer
  1. National Research and Development Project of China 2020YFC0841100; 2016YFD0500304; 2016YFD0500301; 2020YFC0840800; 2020YFC0840900
  2. 2020HY320001; 2016-I2M-2-006
  3. 2017ZX10304402
1000 Förderprogramm
  1. -
  2. Fundamental Research Funds for CAMS of China; CAMS initiative for Innovative Medicine of China
  3. -
1000 Dateien
  1. Age‐related rhesus macaque models of COVID‐19
    Age‐related rhesus macaque models of COVID‐19
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Basic Research Program of China (973 Program) |
    1000 Förderprogramm -
    1000 Fördernummer National Research and Development Project of China 2020YFC0841100; 2016YFD0500304; 2016YFD0500301; 2020YFC0840800; 2020YFC0840900
  2. 1000 joinedFunding-child
    1000 Förderer Chinese Academy of Medical Sciences |
    1000 Förderprogramm Fundamental Research Funds for CAMS of China; CAMS initiative for Innovative Medicine of China
    1000 Fördernummer 2020HY320001; 2016-I2M-2-006
  3. 1000 joinedFunding-child
    1000 Förderer National Mega projects of China for Major Infectious Diseases |
    1000 Förderprogramm -
    1000 Fördernummer 2017ZX10304402
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423999.rdf
1000 Erstellt am 2020-11-04T12:26:24.818+0100
1000 Erstellt von 218
1000 beschreibt frl:6423999
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2020-11-05T08:31:59.314+0100
1000 Objekt bearb. Thu Nov 05 08:31:37 CET 2020
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  1. oai:frl.publisso.de:frl:6423999 |
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