Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

  1. Wang, Zhengyu
  2. Lam, Ka-Lung
  3. Hu, Jiamiao
  4. Ge, Shenghan
  5. Zhou, Arong
  6. Zheng, Baodong
  7. Zeng, Shaoxiao
  8. LIN, Shaoling ORCID logo

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WeightNameValue
1000 Titel
  • Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
1000 Autor/in
  1. Wang, Zhengyu |
  2. Lam, Ka-Lung |
  3. Hu, Jiamiao |
  4. Ge, Shenghan |
  5. Zhou, Arong |
  6. Zheng, Baodong |
  7. Zeng, Shaoxiao |
  8. LIN, Shaoling |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-25
1000 Erschienen in
1000 Quellenangabe
  • 7(2):579-588
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.868 |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/suppl/10.1002/fsn3.868 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD‐induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD‐induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD‐induced obesity.
1000 Sacherschließung
lokal gut microbiota
lokal chlorogenic acid
lokal body weight
lokal obesity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/V2FuZywgWmhlbmd5dQ==|https://frl.publisso.de/adhoc/uri/TGFtLCBLYS1MdW5n|https://frl.publisso.de/adhoc/uri/SHUsIEppYW1pYW8=|https://frl.publisso.de/adhoc/uri/R2UsIFNoZW5naGFu|https://frl.publisso.de/adhoc/uri/WmhvdSwgQXJvbmc=|https://frl.publisso.de/adhoc/uri/WmhlbmcsIEJhb2Rvbmc=|https://frl.publisso.de/adhoc/uri/WmVuZywgU2hhb3hpYW8=|https://orcid.org/0000-0001-7631-1006
1000 Hinweis
  • This article also appears in:Eat Right, Live Healthy: A National Nutrition Month Special Collection
1000 Label
1000 Förderer
  1. China Postdoctoral Science Foundation |
  2. Research Fund for Taiwan‐Straits Postdoctoral Exchange Program |
1000 Fördernummer
  1. 2018M63072
  2. 2018B003
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer China Postdoctoral Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 2018M63072
  2. 1000 joinedFunding-child
    1000 Förderer Research Fund for Taiwan‐Straits Postdoctoral Exchange Program |
    1000 Förderprogramm -
    1000 Fördernummer 2018B003
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6424043.rdf
1000 Erstellt am 2020-11-05T13:16:53.145+0100
1000 Erstellt von 286
1000 beschreibt frl:6424043
1000 Bearbeitet von 286
1000 Zuletzt bearbeitet Thu Nov 05 13:19:31 CET 2020
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1000 Vgl. frl:6424043
1000 Oai Id
  1. oai:frl.publisso.de:frl:6424043 |
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