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1000 Titel
  • 5 challenges in understanding the role of the virome in health and disease
1000 Titelzusatz
  • Five challenges in understanding the role of the virome in health and disease
1000 Autor/in
  1. Wang, David |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-26
1000 Erschienen in
1000 Quellenangabe
  • 16(3):e1008318
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.ppat.1008318 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098563/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Over the past decade, many studies have established linkages between the microbiome and states of health and disease. By contrast, understanding of the corresponding virome (i.e., the set of all viruses, both eukaryotic and prokaryotic, in a given niche) has lagged substantially behind. There are relatively few virome studies in comparison to microbiome studies. Nonetheless, in recent years, there has been an increasing recognition of the importance of the virome as it has been associated with diseases such as HIV and SIV infection [1, 2], inflammatory bowel disease [3], malnutrition [4], graft-versus-host disease [5], and type 1 diabetes [6, 7]. The identification of virome associations with disease is reminiscent of the descriptive studies that emerged in the early days of the bacterial microbiome. As was the case then, the most critical challenge ahead is defining whether the virome plays a causal role in the associated diseases. In addition, there are additional, unique challenges inherent to virome analysis that render it less tractable than the bacterial microbiome.
1000 Sacherschließung
lokal Nucleic acid sequencing
lokal Animal models of infection
lokal Metagenomics
lokal Bacteriophages
lokal RNA sequencing
lokal RNA viruses
lokal Microbiome
lokal Eukaryota
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0001-5598-5079
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. National Institutes of Health |
1000 Fördernummer
  1. R21 NS101371; RC2DK116713; R33 HL137079
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer R21 NS101371; RC2DK116713; R33 HL137079
1000 Objektart article
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1000 @id frl:6424143.rdf
1000 Erstellt am 2020-11-10T16:51:42.213+0100
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1000 Vgl. frl:6424143
1000 Oai Id
  1. oai:frl.publisso.de:frl:6424143 |
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