The HARMONIC project: study design for the assessment of radiation doses and associated cancer risks following cardiac fluoroscopy in childhood

  1. Harbron, Richard ORCID logo
  2. Thierry-Chef, Isabelle ORCID logo
  3. Pearce, Mark ORCID logo
  4. bernier, marie-odile ORCID logo
  5. Dreuil, Serge ORCID logo
  6. Rage, Estelle ORCID logo
  7. Andreassi, Maria Grazia ORCID logo
  8. Picano, Eugenio ORCID logo
  9. Dreger, Steffen ORCID logo
  10. Zeeb, Hajo ORCID logo
  11. Olerud, Hilde Merete ORCID logo
  12. Thevathas, Utheya ORCID logo
  13. Kjaerheim, Kristina ORCID logo
  14. Døhlen, Gaute
  15. Jahnen, Andreas ORCID logo
  16. Hermen, Johannes ORCID logo
  17. Chumak, Vadim ORCID logo
  18. Bakhanova, Elena ORCID logo
  19. Voloskyi, Vitalii ORCID logo
  20. Borrego, David ORCID logo
  21. Lee, Choonsik ORCID logo
  22. Dabin, Jeremie ORCID logo

Download
Harbron-et-al_2020_The HARMONIC project.pdf 930,90KB
WeightNameValue
1000 Titel
  • The HARMONIC project: study design for the assessment of radiation doses and associated cancer risks following cardiac fluoroscopy in childhood
1000 Autor/in
  1. Harbron, Richard |
  2. Thierry-Chef, Isabelle |
  3. Pearce, Mark |
  4. bernier, marie-odile |
  5. Dreuil, Serge |
  6. Rage, Estelle |
  7. Andreassi, Maria Grazia |
  8. Picano, Eugenio |
  9. Dreger, Steffen |
  10. Zeeb, Hajo |
  11. Olerud, Hilde Merete |
  12. Thevathas, Utheya |
  13. Kjaerheim, Kristina |
  14. Døhlen, Gaute |
  15. Jahnen, Andreas |
  16. Hermen, Johannes |
  17. Chumak, Vadim |
  18. Bakhanova, Elena |
  19. Voloskyi, Vitalii |
  20. Borrego, David |
  21. Lee, Choonsik |
  22. Dabin, Jeremie |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-24
1000 Erschienen in
1000 Quellenangabe
  • 40(4):1074–1090
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1088/1361-6498/aba66d |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The HARMONIC project (Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Paediatrics) is a European study aiming to improve our understanding of the long-term health risks from radiation exposures in childhood and early adulthood. Here, we present the study design for the cardiac fluoroscopy component of HARMONIC. A pooled cohort of approximately 100 000 patients who underwent cardiac fluoroscopy procedures in Belgium, France, Germany, Italy, Norway, Spain or the UK, while aged under 22 years, will be established from hospital records and/or insurance claims data. Doses to individual organs will be estimated from dose indicators recorded at the time of examination, using a lookup-table-based dosimetry system produced using Monte Carlo radiation transport simulations and anatomically realistic computational phantom models. Information on beam geometry and x-ray energy spectra will be obtained from a representative sample of radiation dose structured reports. Uncertainties in dose estimates will be modelled using 2D Monte Carlo methods. The cohort will be followed up using national registries and insurance records to determine vital status and cancer incidence. Information on organ transplantation (a major risk factor for cancer development in this patient group) and/or other conditions predisposing to cancer will be obtained from national or local registries and health insurance data, depending on country. The relationship between estimated radiation dose and cancer risk will be investigated using regression modelling. Results will improve information for patients and parents and aid clinicians in managing and implementing changes to reduce radiation risks without compromising medical benefits.
1000 Sacherschließung
lokal Cardiac fluoroscopy
lokal Epidemiology
lokal Monte Carlo
lokal Cancer risks
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6073-2850|https://orcid.org/0000-0001-6304-2783|https://orcid.org/0000-0002-0583-3779|https://orcid.org/0000-0001-5807-4596|https://orcid.org/0000-0002-6160-0670|https://orcid.org/0000-0002-3251-4124|https://orcid.org/0000-0002-2163-0816|https://orcid.org/0000-0002-6375-6361|https://orcid.org/0000-0001-7278-4789|https://orcid.org/0000-0001-7509-242X|https://orcid.org/0000-0002-4940-7130|https://orcid.org/0000-0001-8627-4413|https://orcid.org/0000-0003-0691-3735|https://frl.publisso.de/adhoc/uri/RMO4aGxlbiwgR2F1dGU=|https://orcid.org/0000-0002-7379-5145|https://orcid.org/0000-0002-1198-5701|https://orcid.org/0000-0001-6045-9356|https://orcid.org/0000-0003-3960-5069|https://orcid.org/0000-0002-9520-6372|https://orcid.org/0000-0001-9868-5113|https://orcid.org/0000-0003-4289-9870|https://orcid.org/0000-0002-9462-5807
1000 Label
1000 Förderer
  1. Horizon 2020 |
  2. British Heart Foundation |
1000 Fördernummer
  1. 847707
  2. -
1000 Förderprogramm
  1. Euratom research and training programme 2014–2018
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Horizon 2020 |
    1000 Förderprogramm Euratom research and training programme 2014–2018
    1000 Fördernummer 847707
  2. 1000 joinedFunding-child
    1000 Förderer British Heart Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6424528.rdf
1000 Erstellt am 2020-11-30T12:02:51.355+0100
1000 Erstellt von 266
1000 beschreibt frl:6424528
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri May 13 17:59:49 CEST 2022
1000 Objekt bearb. Fri May 13 17:59:48 CEST 2022
1000 Vgl. frl:6424528
1000 Oai Id
  1. oai:frl.publisso.de:frl:6424528 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source