Prospective community programme versus parent-driven care to prevent respiratory morbidity in children following hospitalisation with severe bronchiolitis or pneumonia

  1. Byrnes, Catherine ORCID logo
  2. Trenholme, Adrian
  3. Lawrence, Shirley
  4. Aish, Harley
  5. Higham, Julie Anne
  6. Hoare, Karen
  7. Elborough, Aileen
  8. McBride, Charissa
  9. Le Comte, Lyndsay
  10. MCIntosh, Christine
  11. Chan Mow, Florina
  12. Jaksic, Mirjana
  13. Metcalfe, Russell
  14. Coomarasamy, Christin
  15. Leung, Wiliam
  16. Vogel, Alison
  17. Percival, Teuila
  18. Mason, Henare
  19. Stewart, Joanna

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WeightNameValue
1000 Titel
  • Prospective community programme versus parent-driven care to prevent respiratory morbidity in children following hospitalisation with severe bronchiolitis or pneumonia
1000 Autor/in
  1. Byrnes, Catherine |
  2. Trenholme, Adrian |
  3. Lawrence, Shirley |
  4. Aish, Harley |
  5. Higham, Julie Anne |
  6. Hoare, Karen |
  7. Elborough, Aileen |
  8. McBride, Charissa |
  9. Le Comte, Lyndsay |
  10. MCIntosh, Christine |
  11. Chan Mow, Florina |
  12. Jaksic, Mirjana |
  13. Metcalfe, Russell |
  14. Coomarasamy, Christin |
  15. Leung, Wiliam |
  16. Vogel, Alison |
  17. Percival, Teuila |
  18. Mason, Henare |
  19. Stewart, Joanna |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-24
1000 Erschienen in
1000 Quellenangabe
  • Epub ahead of print
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1136/thoraxjnl-2019-213142 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231446/ |
1000 Ergänzendes Material
  • https://thorax.bmj.com/content/75/4/298#supplementary-materials |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Hospitalisation with severe lower respiratory tract infection (LRTI) in early childhood is associated with ongoing respiratory symptoms and possible later development of bronchiectasis. We aimed to reduce this intermediate respiratory morbidity with a community intervention programme at time of discharge. METHODS: This randomised, controlled, single-blind trial enrolled children aged <2 years hospitalised for severe LRTI to ‘intervention’ or ‘control’. Intervention was three monthly community clinics treating wet cough with prolonged antibiotics referring non-responders. All other health issues were addressed, and health resilience behaviours were encouraged, with referrals for housing or smoking concerns. Controls followed the usual pathway of parent-initiated healthcare access. After 24 months, all children were assessed by a paediatrician blinded to randomisation for primary outcomes of wet cough, abnormal examination (crackles or clubbing) or chest X-ray Brasfield score ≤22. FINDINGS: 400 children (203 intervention, 197 control) were enrolled in 2011–2012; mean age 6.9 months, 230 boys, 87% Maori/Pasifika ethnicity and 83% from the most deprived quintile. Final assessment of 321/400 (80.3%) showed no differences in presence of wet cough (33.9% intervention, 36.5% controls, relative risk (RR) 0.93, 95% CI 0.69 to 1.25), abnormal examination (21.7% intervention, 23.9% controls, RR 0.92, 95% CI 0.61 to 1.38) or Brasfield score ≤22 (32.4% intervention, 37.9% control, RR 0.85, 95% CI 0.63 to 1.17). Twelve (all intervention) were diagnosed with bronchiectasis within this timeframe. INTERPRETATION: We have identified children at high risk of ongoing respiratory disease following hospital admission with severe LRTI in whom this intervention programme did not change outcomes over 2 years.
1000 Sacherschließung
lokal respiratory infection
lokal paediatric lung disaese
lokal pneumonia
lokal bronchiectasis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-3032-3172|https://frl.publisso.de/adhoc/uri/VHJlbmhvbG1lLCBBZHJpYW4=|https://frl.publisso.de/adhoc/uri/TGF3cmVuY2UsIFNoaXJsZXk=|https://frl.publisso.de/adhoc/uri/QWlzaCwgSGFybGV5|https://frl.publisso.de/adhoc/uri/SGlnaGFtLCBKdWxpZSBBbm5l|https://frl.publisso.de/adhoc/uri/SG9hcmUsIEthcmVu|https://frl.publisso.de/adhoc/uri/RWxib3JvdWdoLCBBaWxlZW4=|https://frl.publisso.de/adhoc/uri/TWNCcmlkZSwgQ2hhcmlzc2E=|https://frl.publisso.de/adhoc/uri/TGUgQ29tdGUsIEx5bmRzYXk=|https://frl.publisso.de/adhoc/uri/TUNJbnRvc2gsIENocmlzdGluZQ==|https://frl.publisso.de/adhoc/uri/Q2hhbiBNb3csIEZsb3JpbmE=|https://frl.publisso.de/adhoc/uri/SmFrc2ljLCBNaXJqYW5h|https://frl.publisso.de/adhoc/uri/TWV0Y2FsZmUsIFJ1c3NlbGw=|https://frl.publisso.de/adhoc/uri/Q29vbWFyYXNhbXksIENocmlzdGlu|https://frl.publisso.de/adhoc/uri/TGV1bmcsIFdpbGlhbQ==|https://frl.publisso.de/adhoc/uri/Vm9nZWwsIEFsaXNvbg==|https://frl.publisso.de/adhoc/uri/UGVyY2l2YWwsIFRldWlsYQ==|https://frl.publisso.de/adhoc/uri/TWFzb24sIEhlbmFyZQ==|https://frl.publisso.de/adhoc/uri/U3Rld2FydCwgSm9hbm5h
1000 Label
1000 Förderer
  1. Health Research Council of New Zealand |
  2. Asthma and Respiratory Foundation NZ |
  3. Lottery Health Research |
  4. Maurice and Phyllis Paykel Trust |
1000 Fördernummer
  1. 10/510
  2. -
  3. -
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. -
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Health Research Council of New Zealand |
    1000 Förderprogramm -
    1000 Fördernummer 10/510
  2. 1000 joinedFunding-child
    1000 Förderer Asthma and Respiratory Foundation NZ |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Lottery Health Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Maurice and Phyllis Paykel Trust |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6424952.rdf
1000 Erstellt am 2020-12-22T10:30:53.697+0100
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1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2021-02-12T08:38:57.618+0100
1000 Objekt bearb. Tue Jan 12 09:36:54 CET 2021
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  1. oai:frl.publisso.de:frl:6424952 |
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