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1000 Titel
  • Behavioral and neurophysiological effects of an intensified robot-assisted therapy in subacute stroke: a case control study
1000 Autor/in
  1. Sehle, Aida |
  2. Stuerner, Jana |
  3. Hassa, Thomas |
  4. Spiteri, Stefan |
  5. Schoenfeld, Mircea Ariel |
  6. Liepert, Joachim |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-11
1000 Erschienen in
1000 Quellenangabe
  • 18(1):6
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12984-020-00792-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798321/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Physical training is able to induce changes at neurophysiological and behavioral level associated with performance changes for the trained movements. The current study explores the effects of an additional intense robot-assisted upper extremity training on functional outcome and motor excitability in subacute stroke patients. METHODS: Thirty moderately to severely affected patients < 3 months after stroke received a conventional inpatient rehabilitation. Based on a case-control principle 15 patients were assigned to receive additional 45 min of robot-assisted therapy (Armeo®Spring) 5 times per week (n = 15, intervention group, IG). The Fugl-Meyer Assessment for the Upper Extremity (FMA-UE) was chosen as primary outcome parameter. Patients were tested before and after a 3-week treatment period as well as after a follow-up period of 2 weeks. Using transcranial magnetic stimulation motor evoked potentials (MEPs) and cortical silent periods were recorded from the deltoid muscle on both sides before and after the intervention period to study effects at neurophysiological level. Statistical analysis was performed with non-parametric tests. Correlation analysis was done with Spearman´s rank correlation co-efficient. RESULTS: Both groups showed a significant improvement in FMA-UE from pre to post (IG: + 10.6 points, control group (CG): + 7.3 points) and from post to follow-up (IG: + 3.9 points, CG: + 3.3 points) without a significant difference between them. However, at neurophysiological level post-intervention MEP amplitudes were significantly larger in the IG but not in the CG. The observed MEP amplitudes changes were positively correlated with FMA-UE changes and with the total amount of robot-assisted therapy. CONCLUSION: The additional robot-assisted therapy induced stronger excitability increases in the intervention group. However, this effect did not transduce to motor performance improvements at behavioral level. Trial registration The trial was registered in German Clinical Trials Register.
1000 Sacherschließung
lokal Stroke
lokal Transcranial magnetic stimulation
lokal Dose–response relationship
lokal Motor recovery
lokal Upper extremity
lokal Robotics
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2VobGUsIEFpZGE=|https://frl.publisso.de/adhoc/uri/U3R1ZXJuZXIsIEphbmE=|https://frl.publisso.de/adhoc/uri/SGFzc2EsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/U3BpdGVyaSwgU3RlZmFu|https://orcid.org/0000-0001-9003-4092|https://orcid.org/0000-0002-3430-7372
1000 Label
1000 Förderer
  1. Lurija Institute, Kliniken Schmieder |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Lurija Institute, Kliniken Schmieder |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6425303.rdf
1000 Erstellt am 2021-01-21T13:54:12.015+0100
1000 Erstellt von 242
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1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 28 10:45:18 CET 2021
1000 Objekt bearb. Thu Jan 28 10:40:07 CET 2021
1000 Vgl. frl:6425303
1000 Oai Id
  1. oai:frl.publisso.de:frl:6425303 |
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