Download
fnins-14-598406.pdf 3,96MB
WeightNameValue
1000 Titel
  • Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma
1000 Autor/in
  1. Jeschke, Marcus |
  2. Happel, Max |
  3. Tziridis, Konstantin |
  4. Krauss, Patrick |
  5. Schilling, Achim |
  6. Schulze, Holger |
  7. Ohl, Frank |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-05
1000 Erschienen in
1000 Quellenangabe
  • 14:598406
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fnins.2020.598406 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813782/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Harmful environmental sounds are a prevailing source of chronic hearing impairments, including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are related to pathophysiological damage to the sensory receptor epithelia and its effects along the auditory pathway, have been documented in numerous studies. An open question concerns the temporal evolution of maladaptive changes after damage and their manifestation in the balance of thalamocortical and corticocortical input to the auditory cortex (ACx). To address these issues, we investigated the loci of plastic reorganizations across the tonotopic axis of the auditory cortex of male Mongolian gerbils (Meriones unguiculatus) acutely after a sound trauma and after several weeks. We used a residual current-source density analysis to dissociate adaptations of intracolumnar input and horizontally relayed corticocortical input to synaptic populations across cortical layers in ACx. A pure tone-based sound trauma caused acute changes of subcortical inputs and corticocortical inputs at all tonotopic regions, particularly showing a broad reduction of tone-evoked inputs at tonotopic regions around the trauma frequency. At other cortical sites, the overall columnar activity acutely decreased, while relative contributions of lateral corticocortical inputs increased. After 4-6 weeks, cortical activity in response to the altered sensory inputs showed a general increase of local thalamocortical input reaching levels higher than before the trauma. Hence, our results suggest a detailed mechanism for overcompensation of altered frequency input in the auditory cortex that relies on a changing balance of thalamocortical and intracortical input and along the frequency gradient of the cortical tonotopic map.
1000 Sacherschließung
lokal corticocortical
lokal auditory cortex
lokal noise-induced hearing loss
lokal circuit level analysis
lokal thalamocortical
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SmVzY2hrZSwgTWFyY3Vz|https://orcid.org/0000-0002-9581-5856|https://frl.publisso.de/adhoc/uri/VHppcmlkaXMsIEtvbnN0YW50aW4=|https://frl.publisso.de/adhoc/uri/S3JhdXNzLCBQYXRyaWNr|https://frl.publisso.de/adhoc/uri/U2NoaWxsaW5nLCBBY2hpbQ==|https://frl.publisso.de/adhoc/uri/U2NodWx6ZSwgSG9sZ2Vy|https://orcid.org/0000-0001-8260-9423
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. SFB-TRR 31, TP A03; SCHU 1272/12-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SFB-TRR 31, TP A03; SCHU 1272/12-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6425309.rdf
1000 Erstellt am 2021-01-22T10:39:56.389+0100
1000 Erstellt von 242
1000 beschreibt frl:6425309
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 28 10:34:11 CET 2021
1000 Objekt bearb. Thu Jan 28 10:33:58 CET 2021
1000 Vgl. frl:6425309
1000 Oai Id
  1. oai:frl.publisso.de:frl:6425309 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source