Download
1-s2.0-S221315822030382X-main.pdf 2,19MB
WeightNameValue
1000 Titel
  • Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease
1000 Autor/in
  1. Machts, Judith |
  2. Keute, Marius |
  3. Kaufmann, Joern |
  4. Schreiber, Stefanie |
  5. Kasper, Elisabeth |
  6. Petri, Susanne |
  7. Prudlo, Johannes |
  8. Vielhaber, Stefan |
  9. Schoenfeld, Mircea Ariel |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-25
1000 Erschienen in
1000 Quellenangabe
  • 29:102545
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.nicl.2020.102545 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786131/ |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S221315822030382X?via%3Dihub#s0125 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Memory impairment in motor neuron disease (MND) is still an underrecognized feature and has traditionally been attributed to executive dysfunction. Here, we investigate the rate of memory impairment in a longitudinal cohort of MND patients, its relationship to other cognitive functions and the underlying neuroanatomical correlates. 142 patients with MND and 99 healthy controls (HC) underwent comprehensive neuropsychological testing and structural MRI at 3T up to four times over a period of 18 months. Linear-mixed effects models were fitted to identify changes at baseline and over time in episodic memory function (learning, immediate and delayed recall, recognition), composed cognitive scores (memory, verbal fluency, executive function), and memory-related structural brain regions (hippocampus, entorhinal cortex, parahippocampal gyrus). Associations between episodic memory performance and volumetric or cortical thickness changes of these regions were computed using Pearson's r. Learning, immediate and delayed recall, as well as recognition performance were significantly reduced in MND when compared to controls at baseline. Performances in these subtests improved over time although MND showed less improvement than controls. This relationship did not change when only "classical" ALS patients were considered. Patients with MND showed thinning of the right parahippocampal gyrus (PhG) in comparison to controls that was progressing over time. Bilateral hippocampal atrophy was observed in MND patients with memory impairment after splitting the group according to their overall episodic memory performance, with the right hippocampus shrinking over time. In MND patients, the bilateral hippocampal atrophy was associated with impairment in learning, recall, and recognition at baseline. In contrast, left PhG thinning was associated with a poorer learning performance. These results show that episodic memory impairment in MND is a frequent cognitive dysfunction. Since deficits are not clearly declining with disease course, an early involvement of this cognitive domain in the disease seems probable. The memory performance-dependent atrophy of the hippocampus and PhG provide evidence for a widespread involvement of these non-motor cortical areas in disease pathology.
1000 Sacherschließung
lokal Entorhinal cortex
lokal Hippocampus
lokal ALS
lokal MND
lokal MRI
lokal Longitudinal episodic memory
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFjaHRzLCBKdWRpdGg=|https://frl.publisso.de/adhoc/uri/S2V1dGUsIE1hcml1cw==|https://frl.publisso.de/adhoc/uri/S2F1Zm1hbm4sIEpvZXJu|https://orcid.org/0000-0003-4439-4374|https://frl.publisso.de/adhoc/uri/S2FzcGVyLCBFbGlzYWJldGg=|https://orcid.org/0000-0002-9783-8584|https://frl.publisso.de/adhoc/uri/UHJ1ZGxvLCBKb2hhbm5lcw==|https://frl.publisso.de/adhoc/uri/VmllbGhhYmVyLCBTdGVmYW4=|https://orcid.org/0000-0001-9003-4092
1000 Label
1000 Förderer
  1. German Centre for Neurodegenerative Diseases |
  2. Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt |
  3. European Regional Development Fund |
1000 Fördernummer
  1. -
  2. ZS/2016/04/78113
  3. ZS/2016/04/78113
1000 Förderprogramm
  1. Cognition in motor neuron disease
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Centre for Neurodegenerative Diseases |
    1000 Förderprogramm Cognition in motor neuron disease
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt |
    1000 Förderprogramm -
    1000 Fördernummer ZS/2016/04/78113
  3. 1000 joinedFunding-child
    1000 Förderer European Regional Development Fund |
    1000 Förderprogramm -
    1000 Fördernummer ZS/2016/04/78113
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6425799.rdf
1000 Erstellt am 2021-02-24T11:59:30.893+0100
1000 Erstellt von 242
1000 beschreibt frl:6425799
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon Mar 22 12:32:48 CET 2021
1000 Objekt bearb. Mon Mar 22 12:32:26 CET 2021
1000 Vgl. frl:6425799
1000 Oai Id
  1. oai:frl.publisso.de:frl:6425799 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source