Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19

  1. Lenti, Marco Vincenzo ORCID logo
  2. Aronico, Nicola
  3. Pellegrino, Ivan
  4. Boveri, Emanuela
  5. Giuffrida, Paolo
  6. Borrelli de Andreis, Federica
  7. Morbini, Patrizia
  8. Vanelli, Laura
  9. Pasini, Alessandra
  10. Ubezio, Cristina
  11. Melazzini, Federica
  12. Rascaroli, Alessandro
  13. Antoci, Valentina
  14. Merli, Stefania
  15. Di Terlizzi, Francesco
  16. Sabatini, Umberto
  17. Cambiè, Ginevra
  18. Tenore, Annamaria
  19. Picone, Cristina
  20. Vanoli, Alessandro
  21. Arcaini, Luca
  22. Baldanti, Fausto
  23. Paulli, Marco
  24. Corazza, Gino Roberto
  25. Di Sabatino, Antonio

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1000 Titel
  • Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19
1000 Autor/in
  1. Lenti, Marco Vincenzo |
  2. Aronico, Nicola |
  3. Pellegrino, Ivan |
  4. Boveri, Emanuela |
  5. Giuffrida, Paolo |
  6. Borrelli de Andreis, Federica |
  7. Morbini, Patrizia |
  8. Vanelli, Laura |
  9. Pasini, Alessandra |
  10. Ubezio, Cristina |
  11. Melazzini, Federica |
  12. Rascaroli, Alessandro |
  13. Antoci, Valentina |
  14. Merli, Stefania |
  15. Di Terlizzi, Francesco |
  16. Sabatini, Umberto |
  17. Cambiè, Ginevra |
  18. Tenore, Annamaria |
  19. Picone, Cristina |
  20. Vanoli, Alessandro |
  21. Arcaini, Luca |
  22. Baldanti, Fausto |
  23. Paulli, Marco |
  24. Corazza, Gino Roberto |
  25. Di Sabatino, Antonio |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-30
1000 Erschienen in
1000 Quellenangabe
  • 10:20836
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-020-77945-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705651/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-020-77945-8#Sec10 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count < 1500/µl were not correlated with IgM memory B cell depletion. A discrete-to-marked reduction of the B-cell compartment was also noticed in autoptic spleen specimens of two COVID-19 patients. We conclude that IgM memory B cells are commonly depleted in COVID-19 patients and this correlates with increased mortality and superimposed infections.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Adaptive immunity
lokal Lymphocytes
lokal Infectious diseases
lokal Immunopathogenesis
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