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1000 Titel
  • Functional properties and adipogenesis inhibitory activity of protein hydrolysates from quinoa (Chenopodium quinoa Willd.)
1000 Autor/in
  1. Shi, Zhenxing |
  2. Hao, Yuqiong |
  3. Teng, Cong |
  4. Yao, Yang |
  5. Ren, Guixing |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-05-17
1000 Erschienen in
1000 Quellenangabe
  • 7(6):2103-2112
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.1052 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The functional properties and adipogenesis inhibitory activity of quinoa protein hydrolysates, prepared using papain, pepsin, and pancreatin for 0, 30, 60, 90, and 120 min, were studied. For these three kinds of proteases, the solubility of the hydrolysates significantly increased with the increasing DH in pH range of 3–8, while the EAI and ESI of these hydrolysates significantly decreased during hydrolysis. The anti‐inflammatory activity of these protein hydrolysates was measured. All of these protein hydrolysates showed high anti‐inflammatory activity. However, there was no significant difference in anti‐inflammatory activity between protein hydrolysates and total protein from quinoa. These protein hydrolysates also inhibited lipid accumulation during differentiation within the range of concentrations of 0–1,600 μg/ml, which exerted no cytotoxicity toward 3T3‐L1 cells. The protein hydrolysates from quinoa prepared using pepsin for 120 min (PEP‐120) had the highest activity with an IC50 value of 786.58 μg/ml. Moreover, LC‐MS/MS analysis of PEP‐120 showed that five main bioactive peptides, which have been demonstrated to have ACE inhibitor, antioxidant, and antithrombotic activities, were present in PEP‐120. In addition, gene expression and Western blot analysis revealed that PEP‐120 suppressed the 3T3‐L1 cell differentiation through the peroxisome proliferator‐activated receptor γ (PPARγ) pathway.
1000 Sacherschließung
lokal anti‐inflammation
lokal quinoa protein hydrolysates
lokal functional properties
lokal adipogenesis inhibitory activity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2hpLCBaaGVueGluZw==|https://frl.publisso.de/adhoc/uri/SGFvLCBZdXFpb25n|https://frl.publisso.de/adhoc/uri/VGVuZywgQ29uZw==|https://orcid.org/0000-0001-7733-930X|https://frl.publisso.de/adhoc/uri/UmVuLCBHdWl4aW5n
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1000 Erstellt am 2021-03-03T12:59:59.640+0100
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