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1000 Titel
  • Deep Brain Stimulation for Refractory Focal Epilepsy: Unraveling the Insertional Effect up to Five Months Without Stimulation
1000 Autor/in
  1. Thuberg, Dominik |
  2. Buentjen, Lars |
  3. Holtkamp, Martin |
  4. Voges, Jürgen |
  5. Heinze, Hans-Jochen |
  6. Lee, Harim |
  7. Kitay, Ann-Yasmin |
  8. Schmitt, Friedhelm C |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-21
1000 Erschienen in
1000 Quellenangabe
  • 24(2):373-379
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/ner.13349 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: Following electrode implantation, a subgroup of patients treated with deep brain stimulation (DBS) for focal epilepsy exhibits a reduction of seizure frequency before stimulation is initiated. Microlesioning of the target structure has been postulated to be the cause of this "insertional" effect (IE). We examined the occurrence and duration of this IE in a group of patients with focal epilepsy following electrode implantation in the anterior nuclei of the thalamus (ANT) and/or nucleus accumbens (NAC) for DBS treatment. MATERIALS AND METHODS: Changes in monthly seizure frequency compared to preoperative baseline were assessed one month (14 patients) and five months (four patients) after electrode implantation. A group analysis between patients with implantation of bilateral ANT-electrodes (four patients), NAC-electrodes (one patient) as well as ANT and NAC-electrodes (nine patients) was performed. RESULTS: In this cohort, seizure frequency decreased one month after electrode implantation by 57.1 ± 30.1%, p ≤ 0.001 (compared to baseline). No significant difference within stimulation target subcohorts was found (p > 0.05). Out of the four patients without stimulation for five months following electrode insertion, three patients showed seizure frequency reduction lasting two to three months, while blinded to their stimulation status. CONCLUSION: An IE might explain seizure frequency reduction in our cohort. This effect seems to be independent of the number of implanted electrodes and of the target itself. The time course of the blinded subgroup of epilepsy patients suggests a peak of the lesional effect at two to three months after electrode insertion.
1000 Sacherschließung
lokal focal epilepsy
lokal nucleus accumbens
lokal deep brain stimulation
lokal Anterior thalamus
lokal microlesional effect
lokal lesional effect
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VGh1YmVyZywgRG9taW5paw==|https://frl.publisso.de/adhoc/uri/QnVlbnRqZW4sIExhcnM=|https://frl.publisso.de/adhoc/uri/SG9sdGthbXAsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/Vm9nZXMsIErDvHJnZW4=|https://frl.publisso.de/adhoc/uri/SGVpbnplLCBIYW5zLUpvY2hlbg==|https://frl.publisso.de/adhoc/uri/TGVlLCBIYXJpbQ==|https://frl.publisso.de/adhoc/uri/S2l0YXksIEFubi1ZYXNtaW4=|https://orcid.org/0000-0003-0361-9215
1000 Label
1000 Förderer
  1. Projekt DEAL |
  2. Bodelschwingh Foundation |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. Open Access Funding
  2. Friedrich‐von‐Bodelschwingh endowed Professorship for Clinical and Experimental Epileptology
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access Funding
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Bodelschwingh Foundation |
    1000 Förderprogramm Friedrich‐von‐Bodelschwingh endowed Professorship for Clinical and Experimental Epileptology
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6426279.rdf
1000 Erstellt am 2021-03-19T15:53:36.290+0100
1000 Erstellt von 242
1000 beschreibt frl:6426279
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon Mar 29 12:24:57 CEST 2021
1000 Objekt bearb. Mon Mar 29 12:24:42 CEST 2021
1000 Vgl. frl:6426279
1000 Oai Id
  1. oai:frl.publisso.de:frl:6426279 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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