Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens

  1. Barnett, Ross
  2. Westbury, Michael V.
  3. Sandoval-Velasco, Marcela
  4. Vieira, Filipe Garrett
  5. Jeon, Sungwon
  6. Zazula, Grant
  7. Martin, Michael D.
  8. Ho, Simon Y.W.
  9. Mather, Niklas
  10. Gopalakrishnan, Shyam
  11. Ramos-Madrigal, Jazmín
  12. de Manuel, Marc
  13. Zepeda-Mendoza, M. Lisandra
  14. Antunes, Agostinho
  15. Baez, Aldo Carmona
  16. De Cahsan, Binia
  17. Larson, Greger
  18. O’Brien, Stephen J.
  19. Eizirik, Eduardo
  20. Johnson, Warren E.
  21. Koepfli, Klaus-Peter
  22. Wilting, Andreas ORCID logo
  23. Fickel, Jörns
  24. Dalén, Love
  25. Lorenzen, Eline D.
  26. Marques-Bonet, Tomas
  27. Hansen, Anders J.
  28. Zhang, Guojie
  29. Bhak, Jong
  30. Yamaguchi, Nobuyuki
  31. Gilbert, M. Thomas P.

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1000 Titel
  • Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens
1000 Autor/in
  1. Barnett, Ross |
  2. Westbury, Michael V. |
  3. Sandoval-Velasco, Marcela |
  4. Vieira, Filipe Garrett |
  5. Jeon, Sungwon |
  6. Zazula, Grant |
  7. Martin, Michael D. |
  8. Ho, Simon Y.W. |
  9. Mather, Niklas |
  10. Gopalakrishnan, Shyam |
  11. Ramos-Madrigal, Jazmín |
  12. de Manuel, Marc |
  13. Zepeda-Mendoza, M. Lisandra |
  14. Antunes, Agostinho |
  15. Baez, Aldo Carmona |
  16. De Cahsan, Binia |
  17. Larson, Greger |
  18. O’Brien, Stephen J. |
  19. Eizirik, Eduardo |
  20. Johnson, Warren E. |
  21. Koepfli, Klaus-Peter |
  22. Wilting, Andreas |
  23. Fickel, Jörns |
  24. Dalén, Love |
  25. Lorenzen, Eline D. |
  26. Marques-Bonet, Tomas |
  27. Hansen, Anders J. |
  28. Zhang, Guojie |
  29. Bhak, Jong |
  30. Yamaguchi, Nobuyuki |
  31. Gilbert, M. Thomas P. |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-21
1000 Erschienen in
1000 Quellenangabe
  • 30(24):5018–5025.e5
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.cub.2020.09.051 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762822/ |
1000 Ergänzendes Material
  • https://www.cell.com/current-biology/fulltext/S0960-9822(20)31421-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982220314214%3Fshowall%3Dtrue#supplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1, 2, 3, 4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6, 7, 8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a ∼7x nuclear genome and a ∼38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (∼22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11, 12, 13, 14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.
1000 Sacherschließung
lokal comparative genomes
lokal genomics
lokal palaeogenome
lokal selection
lokal phylogeny
lokal Homotherium
lokal paleogenome
lokal ancient DNA
lokal adaptation
lokal diversity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Seventh Framework Programme |
  2. H2020 European Research Council |
  3. Walter Reed Army Institute of Research |
1000 Fördernummer
  1. FP7-PEOPLE-2011-IEF-298820
  2. 681396
  3. -
1000 Förderprogramm
  1. -
  2. Extinction Genomics
  3. National Research Council Research Associateship
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer FP7-PEOPLE-2011-IEF-298820
  2. 1000 joinedFunding-child
    1000 Förderer H2020 European Research Council |
    1000 Förderprogramm Extinction Genomics
    1000 Fördernummer 681396
  3. 1000 joinedFunding-child
    1000 Förderer Walter Reed Army Institute of Research |
    1000 Förderprogramm National Research Council Research Associateship
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6426477.rdf
1000 Erstellt am 2021-03-26T12:35:56.196+0100
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1000 Zuletzt bearbeitet Fri May 20 18:33:01 CEST 2022
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