Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

  1. Ebert, Thomas ORCID logo
  2. Painer, Johanna ORCID logo
  3. Bergman, Peter ORCID logo
  4. Qureshi, Abdul Rashid Tony ORCID logo
  5. Giroud, Sylvain ORCID logo
  6. Stalder, Gabrielle
  7. Kublickiene, Karolina
  8. Goeritz, Frank ORCID logo
  9. Vetter, Sebastian G. ORCID logo
  10. Bieber, Claudia ORCID logo
  11. Frobert, Ole ORCID logo
  12. Arnemo, Jon M ORCID logo
  13. Zedrosser, Andreas
  14. Redtenbacher, Irene
  15. Shiels, Paul G.
  16. Johnson, Richard J.
  17. Stenvinkel, Peter ORCID logo

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1000 Titel
  • Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
1000 Autor/in
  1. Ebert, Thomas |
  2. Painer, Johanna |
  3. Bergman, Peter |
  4. Qureshi, Abdul Rashid Tony |
  5. Giroud, Sylvain |
  6. Stalder, Gabrielle |
  7. Kublickiene, Karolina |
  8. Goeritz, Frank |
  9. Vetter, Sebastian G. |
  10. Bieber, Claudia |
  11. Frobert, Ole |
  12. Arnemo, Jon M |
  13. Zedrosser, Andreas |
  14. Redtenbacher, Irene |
  15. Shiels, Paul G. |
  16. Johnson, Richard J. |
  17. Stenvinkel, Peter |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-23
1000 Erschienen in
1000 Quellenangabe
  • 10(1):20323
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-020-76346-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684304/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.
1000 Sacherschließung
lokal Zoology
lokal Nephrology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-1683-9276|https://orcid.org/0000-0003-3929-511X|https://orcid.org/0000-0003-3306-3713|https://orcid.org/0000-0003-0536-5327|https://orcid.org/0000-0001-6621-7462|https://frl.publisso.de/adhoc/uri/U3RhbGRlciwgR2FicmllbGxl|https://frl.publisso.de/adhoc/uri/S3VibGlja2llbmUsIEthcm9saW5h|https://orcid.org/0000-0002-5353-7499|https://orcid.org/0000-0001-5374-5872|https://orcid.org/0000-0001-8919-3117|https://orcid.org/0000-0002-5846-345X|https://orcid.org/0000-0001-8577-896X|https://frl.publisso.de/adhoc/uri/WmVkcm9zc2VyLCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/UmVkdGVuYmFjaGVyLCBJcmVuZQ==|https://frl.publisso.de/adhoc/uri/U2hpZWxzLCBQYXVsIEcu|https://frl.publisso.de/adhoc/uri/Sm9obnNvbiwgUmljaGFyZCBKLg==|https://orcid.org/0000-0002-8785-4820
1000 Label
1000 Förderer
  1. Karolinska Institutet |
  2. Novo Nordisk |
  3. Njurfonden |
  4. AstraZeneca |
  5. Swedish Heart and Lung Foundation |
  6. Svenska Forskningsrådet Formas |
  7. University of Glasgow |
  8. Constant Pharma Ltd |
  9. 4D Pharma Ltd |
  10. Lundbeckfonden |
  11. Augustinus Fonden |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. 20160384
  6. 2009-1068
  7. -
  8. -
  9. -
  10. R126-2012-12408; R194-2015-1108; R286-2018-367
  11. -
1000 Förderprogramm
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  2. -
  3. -
  4. EFSD Mentorship
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Karolinska Institutet |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Novo Nordisk |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Njurfonden |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer AstraZeneca |
    1000 Förderprogramm EFSD Mentorship
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Swedish Heart and Lung Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 20160384
  6. 1000 joinedFunding-child
    1000 Förderer Svenska Forskningsrådet Formas |
    1000 Förderprogramm -
    1000 Fördernummer 2009-1068
  7. 1000 joinedFunding-child
    1000 Förderer University of Glasgow |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer Constant Pharma Ltd |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer 4D Pharma Ltd |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Lundbeckfonden |
    1000 Förderprogramm -
    1000 Fördernummer R126-2012-12408; R194-2015-1108; R286-2018-367
  11. 1000 joinedFunding-child
    1000 Förderer Augustinus Fonden |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6426556.rdf
1000 Erstellt am 2021-03-31T08:00:06.837+0200
1000 Erstellt von 122
1000 beschreibt frl:6426556
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2021-04-23T13:39:12.659+0200
1000 Objekt bearb. Fri Apr 23 13:39:12 CEST 2021
1000 Vgl. frl:6426556
1000 Oai Id
  1. oai:frl.publisso.de:frl:6426556 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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