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1000 Titel
  • COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system
1000 Autor/in
  1. Caraballo, César |
  2. McCullough, Megan |
  3. Fuery, Michael |
  4. Chouairi, Fouad |
  5. Keating, Craig |
  6. Ravindra, Neal G. |
  7. Miller, P. Elliott |
  8. Malinis, Maricar |
  9. Kashyap, Nitu |
  10. Hsiao, Allen |
  11. Wilson, F. Perry |
  12. Curtis, Jeptha P. |
  13. Grant, Matthew |
  14. Velazquez, Eric J. |
  15. Desai, Nihar R. |
  16. Ahmad, Tariq |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-30
1000 Erschienen in
1000 Quellenangabe
  • 15(9):e0238829
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0238829 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526909/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238829#sec014 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Patients with comorbid conditions have a higher risk of mortality with SARS-CoV-2 (COVID-19) infection, but the impact on heart failure patients living near a disease hotspot is unknown. Therefore, we sought to characterize the prevalence and outcomes of COVID-19 in a live registry of heart failure patients across an integrated health care system in Connecticut. METHODS: In this retrospective analysis, the Yale Heart Failure Registry (NCT04237701) that includes 26,703 patients with heart failure across a 6-hospital integrated health care system in Connecticut was queried on April 16th, 2020 for all patients tested for COVID-19. Sociodemographic and geospatial data as well as, clinical management, respiratory failure, and patient mortality were obtained via the real-time registry. Data on COVID-19 specific care was extracted by retrospective chart review. RESULTS: COVID-19 testing was performed on 900 symptomatic patients, comprising 3.4% of the Yale Heart Failure Registry (N = 26,703). Overall, 206 (23%) were COVID- 19+. As compared to COVID-19-, these patients were more likely to be older, black, have hypertension, coronary artery disease, and were less likely to be on renin angiotensin blockers (P<0.05, all). COVID-19- patients tended to be more diffusely spread across the state whereas COVID-19+ were largely clustered around urban centers. 20% of COVID-19+ patients died, and age was associated with increased risk of death [OR 1.92 95% CI (1.33–2.78); P<0.001]. Among COVID-19+ patients who were ≥85 years of age rates of hospitalization were 87%, rates of death 36%, and continuing hospitalization 62% at time of manuscript preparation. CONCLUSIONS: In this real-world snapshot of COVID-19 infection among a large cohort of heart failure patients, we found that a small proportion had undergone testing. Patients found to be COVID-19+ tended to be black with multiple comorbidities and clustered around lower socioeconomic status communities. Elderly COVID-19+ patients were very likely to be admitted to the hospital and experience high rates of mortality.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Medical risk factors
lokal Heart failure
lokal Respiratory infections
lokal Virus testing
lokal Intensive care units
lokal Geriatric care
lokal Death rates
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1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4557-9437|https://frl.publisso.de/adhoc/uri/TWNDdWxsb3VnaCwgTWVnYW4=|https://orcid.org/0000-0001-9166-4838|https://frl.publisso.de/adhoc/uri/Q2hvdWFpcmksIEZvdWFk|https://frl.publisso.de/adhoc/uri/S2VhdGluZywgQ3JhaWc=|https://frl.publisso.de/adhoc/uri/UmF2aW5kcmEsIE5lYWwgRy4=|https://frl.publisso.de/adhoc/uri/TWlsbGVyLCBQLiBFbGxpb3R0|https://frl.publisso.de/adhoc/uri/TWFsaW5pcywgTWFyaWNhcg==|https://frl.publisso.de/adhoc/uri/S2FzaHlhcCwgTml0dQ==|https://frl.publisso.de/adhoc/uri/SHNpYW8sIEFsbGVu|https://frl.publisso.de/adhoc/uri/V2lsc29uLCBGLiBQZXJyeQ==|https://frl.publisso.de/adhoc/uri/Q3VydGlzLCBKZXB0aGEgUC4=|https://frl.publisso.de/adhoc/uri/R3JhbnQsIE1hdHRoZXc=|https://frl.publisso.de/adhoc/uri/VmVsYXpxdWV6LCBFcmljIEou|https://frl.publisso.de/adhoc/uri/RGVzYWksIE5paGFyIFIu|https://orcid.org/0000-0001-7596-4697
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1000 Erstellt am 2021-04-08T11:35:46.789+0200
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