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WeightNameValue
1000 Titel
  • Noradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway
1000 Autor/in
  1. Valero-Aracama, Maria Jesus |
  2. Reboreda, Antonio |
  3. Arboit, Alberto |
  4. Sauvage, Magdalena |
  5. Yoshida, Motoharu |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-26
1000 Erschienen in
1000 Quellenangabe
  • 8(2):ENEURO.0440-20.2020
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1523/ENEURO.0440-20.2020 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009666/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Persistent firing is believed to be a cellular correlate of working memory. While the effects of noradrenaline (NA) on working memory have widely been described, its effect on the cellular mechanisms of persistent firing remains largely unknown. Using in vitro intracellular recordings, we demonstrate that persistent firing is supported by individual neurons in hippocampal CA1 pyramidal cells through cholinergic receptor activation, but is dramatically attenuated by NA. In contrast to the classical theory that recurrent synaptic excitation supports persistent firing, suppression of persistent firing by NA was independent of synaptic transmission, indicating that the mechanism is intrinsic to individual cells. In agreement with detrimental effects of cAMP on working memory, we demonstrate that the suppressive effect of NA was through cAMP-PKA pathway. In addition, activation of β1 and/or β3 adrenergic receptors, which increases cAMP levels, suppressed persistent firing. These results are in line with working memory decline observed during high levels of NA and cAMP, which are implicated in high stress, aging, and schizophrenia.
1000 Sacherschließung
lokal β1 adrenoceptors
lokal persistent firing
lokal PKA
lokal M2/4 receptors
lokal cAMP
lokal M1 receptor
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VmFsZXJvLUFyYWNhbWEsIE1hcmlhIEplc3Vz|https://frl.publisso.de/adhoc/uri/UmVib3JlZGEsIEFudG9uaW8=|https://frl.publisso.de/adhoc/uri/QXJib2l0LCBBbGJlcnRv|https://orcid.org/0000-0002-7586-6410|https://orcid.org/0000-0002-0063-9969
1000 Label
1000 Förderer
  1. Stiftung Mercator |
  2. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. YO177/4-1; YO177/7-1
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Stiftung Mercator |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer YO177/4-1; YO177/7-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427004.rdf
1000 Erstellt am 2021-04-21T14:12:51.313+0200
1000 Erstellt von 242
1000 beschreibt frl:6427004
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu May 06 10:40:36 CEST 2021
1000 Objekt bearb. Thu May 06 10:40:25 CEST 2021
1000 Vgl. frl:6427004
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427004 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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