pone.0239800.pdf 1,86MB
1000 Titel
  • Global convergence of COVID-19 basic reproduction number and estimation from early-time SIR dynamics
1000 Autor/in
  1. Katul, Gabriel |
  2. Mrad, Assaad |
  3. Bonetti, Sara |
  4. Manoli, Gabriele |
  5. Parolari, Anthony |
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-24
1000 Erschienen in
1000 Quellenangabe
  • 15(9):e0239800
1000 Copyrightjahr
  • 2020
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  • |
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1000 Abstract/Summary
  • The SIR (‘susceptible-infectious-recovered’) formulation is used to uncover the generic spread mechanisms observed by COVID-19 dynamics globally, especially in the early phases of infectious spread. During this early period, potential controls were not effectively put in place or enforced in many countries. Hence, the early phases of COVID-19 spread in countries where controls were weak offer a unique perspective on the ensemble-behavior of COVID-19 basic reproduction number Ro inferred from SIR formulation. The work here shows that there is global convergence (i.e., across many nations) to an uncontrolled Ro = 4.5 that describes the early time spread of COVID-19. This value is in agreement with independent estimates from other sources reviewed here and adds to the growing consensus that the early estimate of Ro = 2.2 adopted by the World Health Organization is low. A reconciliation between power-law and exponential growth predictions is also featured within the confines of the SIR formulation. The effects of testing ramp-up and the role of ‘super-spreaders’ on the inference of Ro are analyzed using idealized scenarios. Implications for evaluating potential control strategies from this uncontrolled Ro are briefly discussed in the context of the maximum possible infected fraction of the population (needed to assess health care capacity) and mortality (especially in the USA given diverging projections). Model results indicate that if intervention measures still result in Ro > 2.7 within 44 days after first infection, intervention is unlikely to be effective in general for COVID-19.
1000 Sacherschließung
lokal Epidemiology
gnd 1206347392 COVID-19
lokal Infectious disease epidemiology
lokal Italy
lokal Virus testing
lokal Mathematical models
lokal Dynamical systems
lokal Death rates
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