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1000 Titel
  • Eating to dare - Nutrition impacts human risky decision and related brain function
1000 Autor/in
  1. Liu, Lu |
  2. Artigas, Sergio Oroz |
  3. Ulrich, Anja |
  4. Tardu, Jeremy |
  5. Mohr, Peter N. C. |
  6. Wilms, Britta |
  7. Koletzko, Berthold |
  8. Schmid, Sebastian M. |
  9. Park, Soyoung Q. |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-12
1000 Erschienen in
1000 Quellenangabe
  • 233:117951
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.neuroimage.2021.117951 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1053811921002287?via%3Dihub#sec0024 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Macronutrient composition modulates plasma amino acids that are precursors of neurotransmitters and can impact brain function and decisions. Neurotransmitter serotonin has been shown to regulate not only food intake, but also economic decisions. We investigated whether an acute nutrition-manipulation inducing plasma tryptophan fluctuation affects brain function, thereby affecting risky decisions. Breakfasts differing in carbohydrate/protein ratios were offered to test changes in risky decision-making while metabolic and neural dynamics were tracked. We identified that a high-carbohydrate/protein breakfast increased plasma tryptophan/LNAA (large neutral amino acids) ratio which mapped to individual risk propensity changes. The nutrition-manipulation and tryptophan/LNAA fluctuation effects on risk propensity changes were further modulated by individual differences in body fat mass. Using fMRI, we further identified activation in the parietal lobule during risk-processing, of which activities 1) were sensitive to the tryptophan/LNAA fluctuation, 2) were modulated by individual's body fat mass, and 3) predicted the risk propensity changes in decision-making. Our results provide evidence for a personalized nutrition-driven modulation on human risky decision and its metabolic and neural mechanisms.
1000 Sacherschließung
lokal Fat mass
lokal Risky decision-making
lokal Parietal lobule
lokal Macronutrient
lokal Serotonin
lokal Tryptophan
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TGl1LCBMdQ==|https://frl.publisso.de/adhoc/uri/QXJ0aWdhcywgU2VyZ2lvIE9yb3o=|https://frl.publisso.de/adhoc/uri/VWxyaWNoLCBBbmph|https://frl.publisso.de/adhoc/uri/VGFyZHUsIEplcmVteQ==|https://frl.publisso.de/adhoc/uri/TW9ociwgUGV0ZXIgTi4gQy4=|https://frl.publisso.de/adhoc/uri/V2lsbXMsIEJyaXR0YQ==|https://frl.publisso.de/adhoc/uri/S29sZXR6a28sIEJlcnRob2xk|https://frl.publisso.de/adhoc/uri/U2NobWlkLCBTZWJhc3RpYW4gTS4=|https://frl.publisso.de/adhoc/uri/UGFyaywgU295b3VuZyBRLg==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. German Centre for Diabetes Research (DZD) |
  3. Bundesministerium für Bildung und Forschung |
  4. State of Brandenburg |
1000 Fördernummer
  1. PA 2682/1–1
  2. 82DZD00902
  3. -
  4. 82DZD03D03; DZDG16001; 82DZD0C2
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer PA 2682/1–1
  2. 1000 joinedFunding-child
    1000 Förderer German Centre for Diabetes Research (DZD) |
    1000 Förderprogramm -
    1000 Fördernummer 82DZD00902
  3. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer State of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer 82DZD03D03; DZDG16001; 82DZD0C2
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427738.rdf
1000 Erstellt am 2021-05-27T10:49:50.069+0200
1000 Erstellt von 25
1000 beschreibt frl:6427738
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu May 27 10:51:06 CEST 2021
1000 Objekt bearb. Thu May 27 10:50:40 CEST 2021
1000 Vgl. frl:6427738
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427738 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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