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1000 Titel
  • Similar dietary regulation of IGF-1- and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes
1000 Autor/in
  1. Schüler, Rita |
  2. Markova, Mariya |
  3. Osterhoff, Martin A. |
  4. Arafat, Ayman |
  5. Pivovarova, Olga |
  6. Machann, Jürgen |
  7. Hierholzer, Johannes |
  8. Hornemann, Silke |
  9. Rohn, Sascha |
  10. Pfeiffer, Andreas F.H. |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-08
1000 Erschienen in
1000 Quellenangabe
  • 10.1007/s00394-021-02518-y
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00394-021-02518-y |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared the effects of animal versus plant protein intake on circulating levels of IGF-1 and the IGF-binding proteins (IGFBP)-1 and IGFBP-2 over a 6-week period. Thirty seven participants with type 2 diabetes consumed isocaloric diets composed of either 30% energy (EN) animal or plant protein, 30% EN fat and 40% EN carbohydrates for 6 weeks. The participants were clinically phenotyped before and at the end of the study. Both diets induced similar and significant increases of IGF-1 which was unaffected by the different amino acid compositions of plant and animal protein. Despite improvements of insulin sensitivity and major reductions of liver fat, IGFBP2 decreased with both diets while IGFBP-1 was not altered. We conclude that animal and plant protein similarly increase IGF-1 bioavailability while improving metabolic parameters and may be regarded as equivalent in this regard.
1000 Sacherschließung
lokal Animal protein
lokal Growth hormone
lokal IGF-binding protein-2
lokal Plant protein
lokal Insulin-like growth factor-1
lokal Protein intake
lokal IGF-binding protein-1
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Now7xsZXIsIFJpdGE=|https://frl.publisso.de/adhoc/uri/TWFya292YSwgTWFyaXlh|https://frl.publisso.de/adhoc/uri/T3N0ZXJob2ZmLCBNYXJ0aW4gQS4=|https://frl.publisso.de/adhoc/uri/QXJhZmF0LCBBeW1hbg==|https://frl.publisso.de/adhoc/uri/UGl2b3Zhcm92YSwgT2xnYQ==|https://frl.publisso.de/adhoc/uri/TWFjaGFubiwgSsO8cmdlbg==|https://frl.publisso.de/adhoc/uri/SGllcmhvbHplciwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/SG9ybmVtYW5uLCBTaWxrZQ==|https://frl.publisso.de/adhoc/uri/Um9obiwgU2FzY2hh|https://orcid.org/0000-0002-6887-0016
1000 Label
1000 Förderer
  1. Bundesanstalt für Landwirtschaft und Ernährung |
  2. Projekt DEAL |
1000 Fördernummer
  1. 2815407110
  2. -
1000 Förderprogramm
  1. -
  2. Open Access funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesanstalt für Landwirtschaft und Ernährung |
    1000 Förderprogramm -
    1000 Fördernummer 2815407110
  2. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427758.rdf
1000 Erstellt am 2021-05-28T07:11:04.862+0200
1000 Erstellt von 25
1000 beschreibt frl:6427758
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri May 28 07:12:35 CEST 2021
1000 Objekt bearb. Fri May 28 07:12:06 CEST 2021
1000 Vgl. frl:6427758
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427758 |
1000 Sichtbarkeit Metadaten public
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