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1000 Titel
  • Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases
1000 Autor/in
  1. Qian, Youkun |
  2. Zhu, Yicheng |
  3. Li, Yangyang |
  4. Li, Bin |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-02
1000 Erschienen in
1000 Quellenangabe
  • 11:624411
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2020.624411 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884312 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • SARS-CoV-2 is wreaking havoc around the world. To get the world back on track, hundreds of vaccines are under development. A deeper understanding of how the immune system responds to SARS-CoV-2 re-infection will certainly help. Studies have highlighted various aspects of T cell response in resolving acute infection and preventing re-infections. Lung resident memory T (TRM) cells are sentinels in the secondary immune response. They are mostly differentiated from effector T cells, construct specific niches and stay permanently in lung tissues. If the infection recurs, locally activated lung TRM cells can elicit rapid immune response against invading pathogens. In addition, they can significantly limit tumor growth or lead to pathologic immune responses. Vaccines targeting TRM cells are under development, with the hope to induce stable and highly reactive lung TRM cells through mucosal administration or “prime-and-pull” strategy. In this review, we will summarize recent advances in lung TRM cell generation and maintenance, explore their roles in different diseases and discuss how these cells may guide the development of future vaccines targeting infectious disease, cancer, and pathologic immune response.
1000 Sacherschließung
lokal cancer
gnd 1206347392 COVID-19
lokal asthma
lokal lung
lokal infection
lokal tissue-resident memory T cells
lokal vaccine
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UWlhbiwgWW91a3Vu|https://frl.publisso.de/adhoc/uri/Wmh1LCBZaWNoZW5n|https://frl.publisso.de/adhoc/uri/TGksIFlhbmd5YW5n|https://frl.publisso.de/adhoc/uri/TGksIEJpbg==
1000 Label
1000 Förderer
  1. China National Funds for Distinguished Young Scientists |
  2. National Natural Science Foundation of China |
  3. National Key Research and Development Program of China |
  4. China Postdoctoral Science Foundation |
1000 Fördernummer
  1. 31525008
  2. 81830051; 31700775; 31961133011
  3. 2019YFA0906100
  4. 2017M631497
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer China National Funds for Distinguished Young Scientists |
    1000 Förderprogramm -
    1000 Fördernummer 31525008
  2. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer 81830051; 31700775; 31961133011
  3. 1000 joinedFunding-child
    1000 Förderer National Key Research and Development Program of China |
    1000 Förderprogramm -
    1000 Fördernummer 2019YFA0906100
  4. 1000 joinedFunding-child
    1000 Förderer China Postdoctoral Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 2017M631497
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427861.rdf
1000 Erstellt am 2021-06-01T12:49:13.311+0200
1000 Erstellt von 284
1000 beschreibt frl:6427861
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Nov 10 10:11:06 CET 2021
1000 Objekt bearb. Wed Nov 10 10:10:54 CET 2021
1000 Vgl. frl:6427861
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427861 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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