Systems serology detects functionally distinct coronavirus antibody features in children and elderly

  1. Selva, Kevin J.
  2. van de Sandt, Carolien ORCID logo
  3. Lemke, Melissa ORCID logo
  4. Lee, Christina ORCID logo
  5. Shoffner-Beck, Suzanne ORCID logo
  6. Chua, Brendon Y.
  7. Davis, Samantha ORCID logo
  8. NGUYEN, THI HOANG OANH ORCID logo
  9. Rowntree, Louise C.
  10. Hensen, Luca ORCID logo
  11. Koutsakos, Marios
  12. Wong, Chinn Yi
  13. Mordant, Francesca ORCID logo
  14. Jackson, David ORCID logo
  15. Flanagan, Katie ORCID logo
  16. Crowe, Jane
  17. Tosif, Shidan ORCID logo
  18. Neeland, Melanie ORCID logo
  19. Sutton, Philip ORCID logo
  20. Licciardi, Paul ORCID logo
  21. Crawford, Nigel W.
  22. Cheng, Allen C.
  23. Doolan, Denise ORCID logo
  24. Amanat, Fatima ORCID logo
  25. Krammer, Florian ORCID logo
  26. Chappell, Keith
  27. Modhiran, Naphak ORCID logo
  28. Watterson, Daniel ORCID logo
  29. Young, Paul
  30. Lee, Wen Shi ORCID logo
  31. Wines, Bruce ORCID logo
  32. Mark Hogarth, P.
  33. Esterbauer, Robyn ORCID logo
  34. Kelly, Hannah G.
  35. Tan, Hyon-Xhi
  36. Juno, Jennifer ORCID logo
  37. Wheatley, Adam ORCID logo
  38. Kent, Stephen ORCID logo
  39. Arnold, Kelly ORCID logo
  40. Kedzierska, Katherine ORCID logo
  41. Chung, Amy ORCID logo

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1000 Titel
  • Systems serology detects functionally distinct coronavirus antibody features in children and elderly
1000 Autor/in
  1. Selva, Kevin J. |
  2. van de Sandt, Carolien |
  3. Lemke, Melissa |
  4. Lee, Christina |
  5. Shoffner-Beck, Suzanne |
  6. Chua, Brendon Y. |
  7. Davis, Samantha |
  8. NGUYEN, THI HOANG OANH |
  9. Rowntree, Louise C. |
  10. Hensen, Luca |
  11. Koutsakos, Marios |
  12. Wong, Chinn Yi |
  13. Mordant, Francesca |
  14. Jackson, David |
  15. Flanagan, Katie |
  16. Crowe, Jane |
  17. Tosif, Shidan |
  18. Neeland, Melanie |
  19. Sutton, Philip |
  20. Licciardi, Paul |
  21. Crawford, Nigel W. |
  22. Cheng, Allen C. |
  23. Doolan, Denise |
  24. Amanat, Fatima |
  25. Krammer, Florian |
  26. Chappell, Keith |
  27. Modhiran, Naphak |
  28. Watterson, Daniel |
  29. Young, Paul |
  30. Lee, Wen Shi |
  31. Wines, Bruce |
  32. Mark Hogarth, P. |
  33. Esterbauer, Robyn |
  34. Kelly, Hannah G. |
  35. Tan, Hyon-Xhi |
  36. Juno, Jennifer |
  37. Wheatley, Adam |
  38. Kent, Stephen |
  39. Arnold, Kelly |
  40. Kedzierska, Katherine |
  41. Chung, Amy |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-01
1000 Erschienen in
1000 Quellenangabe
  • 12(1):2037
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-021-22236-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016934/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-021-22236-7#Sec29 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand such divergent clinical outcomes. Here we show analysis of coronavirus antibody responses of pre-pandemic healthy children (n = 89), adults (n = 98), elderly (n = 57), and COVID-19 patients (n = 50) by systems serology. Moderate levels of cross-reactive, but non-neutralizing, SARS-CoV-2 antibodies are detected in pre-pandemic healthy individuals. SARS-CoV-2 antigen-specific Fcγ receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS-CoV-2 infection induces qualitative changes to antibody Fc, enhancing Fcγ receptor engagement. Higher cross-reactive SARS-CoV-2 IgA and IgG are observed in healthy elderly, while healthy children display elevated SARS-CoV-2 IgM, suggesting that children have fewer hCoV exposures, resulting in less-experienced but more polyreactive humoral immunity. Age-dependent analysis of COVID-19 patients, confirms elevated class-switched antibodies in elderly, while children have stronger Fc responses which we demonstrate are functionally different. These insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics.
1000 Sacherschließung
lokal Antibodies
lokal SARS-CoV-2
gnd 1206347392 COVID-19
lokal Infection
lokal Viral infection
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2VsdmEsIEtldmluIEou|https://orcid.org/0000-0002-4155-7433|https://orcid.org/0000-0003-1860-4550|https://orcid.org/0000-0002-9393-2178|https://orcid.org/0000-0003-0010-6318|https://frl.publisso.de/adhoc/uri/Q2h1YSwgQnJlbmRvbiBZLg==|https://orcid.org/0000-0002-6197-4277|https://orcid.org/0000-0002-9294-7693|https://frl.publisso.de/adhoc/uri/Um93bnRyZWUsIExvdWlzZSBDLg==|https://orcid.org/0000-0001-8467-8537|https://frl.publisso.de/adhoc/uri/S291dHNha29zLCBNYXJpb3M=|https://frl.publisso.de/adhoc/uri/V29uZywgQ2hpbm4gWWk=|https://orcid.org/0000-0002-3754-2642|https://orcid.org/0000-0001-7255-270X|https://orcid.org/0000-0002-1575-1953|https://frl.publisso.de/adhoc/uri/Q3Jvd2UsIEphbmU=|https://orcid.org/0000-0003-0022-1009|https://orcid.org/0000-0001-7301-9982|https://orcid.org/0000-0003-3129-1800|https://orcid.org/0000-0001-6086-6285|https://frl.publisso.de/adhoc/uri/Q3Jhd2ZvcmQsIE5pZ2VsIFcu|https://frl.publisso.de/adhoc/uri/Q2hlbmcsIEFsbGVuIEMu|https://orcid.org/0000-0001-7354-8817|https://orcid.org/0000-0002-8029-8227|https://orcid.org/0000-0003-4121-776X|https://frl.publisso.de/adhoc/uri/Q2hhcHBlbGwsIEtlaXRo|https://orcid.org/0000-0003-3205-4970|https://orcid.org/0000-0001-5957-2853|https://frl.publisso.de/adhoc/uri/WW91bmcsIFBhdWw=|https://orcid.org/0000-0001-7285-4054|https://orcid.org/0000-0002-4108-375X|https://frl.publisso.de/adhoc/uri/TWFyayBIb2dhcnRoLCBQLg==|https://orcid.org/0000-0002-7091-0048|https://frl.publisso.de/adhoc/uri/S2VsbHksIEhhbm5haCBHLg==|https://frl.publisso.de/adhoc/uri/VGFuLCBIeW9uLVhoaQ==|https://orcid.org/0000-0002-9072-1017|https://orcid.org/0000-0002-5593-9387|https://orcid.org/0000-0002-8539-4891|https://orcid.org/0000-0003-4756-7461|https://orcid.org/0000-0001-6141-335X|https://orcid.org/0000-0003-0020-9704
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1000 Erstellt am 2021-07-06T14:20:58.857+0200
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