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1000 Titel
  • Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study
1000 Autor/in
  1. Gonzalez Escamilla, Gabriel |
  2. Chirumamilla, Venkata C. |
  3. Meyer, Benjamin |
  4. Bonertz, Tamara |
  5. Vogt, Johannes |
  6. von Grotthus, Sarah |
  7. Stroh, Albrecht |
  8. Horstmann, Johann-Philipp |
  9. Tuescher, Oliver |
  10. Kalisch, Raffael |
  11. Muthuraman, Muthuraman |
  12. Groppa, Sergiu |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-09-28
1000 Erschienen in
1000 Quellenangabe
  • 8:14506
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-018-32781-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162240 |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-32781-9#Sec17 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could lead to mental illness. Notwithstanding, non-invasive paradigms to measure excitability regulation during fear processing in humans are missing. To address this challenge we adapted an approach for excitability characterization, combining electroencephalography (EEG) and transcranial magnetic stimulation (TMS) over the dmPFC during an instructed fear paradigm, to dynamically dissect its role in fear processing. Event-related (ERP) and TMS-evoked potentials (TEP) were analyzed to trace dmPFC excitability. We further linked the excitability regulation patterns to individual MRI-derived gray matter structural integrity of the fear network. Increased cortical excitability was demonstrated to threat (T) processing in comparison to no-threat (NT), reflected by increased amplitude of evoked potentials. Furthermore, TMS at dmPFC enhanced the evoked responses during T processing, while the structural integrity of the dmPFC and amygdala predicted the excitability regulation patterns to fear processing. The dmPFC takes a special role during fear processing by dynamically regulating excitability. The applied paradigm can be used to non-invasively track response abnormalities to threat stimuli in healthy subjects or patients with mental disorders.
1000 Sacherschließung
lokal Dorsomedial Prefrontal Cortex
lokal Fear Paradigm
lokal TMS-evoked Potentials (TEPs)
lokal Fear Network
lokal Fear Processing
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-7209-1736|https://frl.publisso.de/adhoc/uri/Q2hpcnVtYW1pbGxhLCBWZW5rYXRhIEMu|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIEJlbmphbWlu|https://frl.publisso.de/adhoc/uri/Qm9uZXJ0eiwgVGFtYXJh|https://frl.publisso.de/adhoc/uri/Vm9ndCwgSm9oYW5uZXMg|https://frl.publisso.de/adhoc/uri/dm9uIEdyb3R0aHVzLCBTYXJhaA==|https://orcid.org/0000-0001-9410-4086|https://frl.publisso.de/adhoc/uri/SG9yc3RtYW5uLCBKb2hhbm4tUGhpbGlwcA==|https://orcid.org/0000-0002-4023-5301|https://frl.publisso.de/adhoc/uri/S2FsaXNjaCwgUmFmZmFlbA==|https://frl.publisso.de/adhoc/uri/TXV0aHVyYW1hbiwgTXV0aHVyYW1hbg==|https://frl.publisso.de/adhoc/uri/R3JvcHBhLCBTZXJnaXU=
1000 Label
1000 Förderer
  1. Johannes Gutenberg-Universität Mainz |
  2. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. CRC-TR-1193
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Johannes Gutenberg-Universität Mainz |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer CRC-TR-1193
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6428890.rdf
1000 Erstellt am 2021-08-13T14:40:09.335+0200
1000 Erstellt von 218
1000 beschreibt frl:6428890
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Aug 19 07:48:31 CEST 2021
1000 Objekt bearb. Thu Aug 19 07:48:20 CEST 2021
1000 Vgl. frl:6428890
1000 Oai Id
  1. oai:frl.publisso.de:frl:6428890 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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