Download
s41366-021-00795-5.pdf 973,90KB
WeightNameValue
1000 Titel
  • Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents
1000 Autor/in
  1. Hüls, Anke |
  2. Wright, Marvin |
  3. Bogl, Leonie H. |
  4. Kaprio, Jaakko |
  5. Lissner, Lauren |
  6. Molnar, Denes |
  7. Moreno Aznar, Luis A. |
  8. De Henauw, Stefaan |
  9. Siani, Alfonso |
  10. Veidebaum, Toomas |
  11. Ahrens, Wolfgang |
  12. Pigeot, Iris |
  13. Foraita, Ronja |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-22
1000 Erschienen in
1000 Quellenangabe
  • 45(6):1321-1330
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1038/s41366-021-00795-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159747/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41366-021-00795-5#Sec20 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Childhood obesity is a complex multifaceted condition, which is influenced by genetics, environmental factors, and their interaction. However, these interactions have mainly been studied in twin studies and evidence from population-based cohorts is limited. Here, we analyze the interaction of an obesity-related genome-wide polygenic risk score (PRS) with sociodemographic and lifestyle factors for BMI and waist circumference (WC) in European children and adolescents. METHODS: The analyses are based on 8609 repeated observations from 3098 participants aged 2–16 years from the IDEFICS/I.Family cohort. A genome-wide polygenic risk score (PRS) was calculated using summary statistics from independent genome-wide association studies of BMI. Associations were estimated using generalized linear mixed models adjusted for sex, age, region of residence, parental education, dietary intake, relatedness, and population stratification. RESULTS: The PRS was associated with BMI (beta estimate [95% confidence interval (95%—CI)] = 0.33 [0.30, 0.37], r2 = 0.11, p value = 7.9 × 10−81) and WC (beta [95%—CI] = 0.36 [0.32, 0.40], r2 = 0.09, p value = 1.8 × 10−71). We observed significant interactions with demographic and lifestyle factors for BMI as well as WC. Children from Southern Europe showed increased genetic liability to obesity (BMI: beta [95%—CI] = 0.40 [0.34, 0.45]) in comparison to children from central Europe (beta [95%—CI] = 0.29 [0.23, 0.34]), p-interaction = 0.0066). Children of parents with a low level of education showed an increased genetic liability to obesity (BMI: beta [95%—CI] = 0.48 [0.38, 0.59]) in comparison to children of parents with a high level of education (beta [95%—CI] = 0.30 [0.26, 0.34]), p-interaction = 0.0012). Furthermore, the genetic liability to obesity was attenuated by a higher intake of fiber (BMI: beta [95%—CI] interaction = −0.02 [−0.04,−0.01]) and shorter screen times (beta [95%—CI] interaction = 0.02 [0.00, 0.03]). CONCLUSIONS: Our results highlight that a healthy childhood environment might partly offset a genetic predisposition to obesity during childhood and adolescence.
1000 Sacherschließung
lokal Genetics
lokal Risk factors
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6005-417X|https://orcid.org/0000-0002-8542-6291|https://frl.publisso.de/adhoc/uri/Qm9nbCwgTGVvbmllIEgu|https://orcid.org/0000-0002-3716-2455|https://frl.publisso.de/adhoc/uri/TGlzc25lciwgTGF1cmVu|https://orcid.org/0000-0002-3675-7019|https://orcid.org/0000-0003-0454-653X|https://frl.publisso.de/adhoc/uri/RGUgSGVuYXV3LCBTdGVmYWFu|https://orcid.org/0000-0002-9797-2943|https://frl.publisso.de/adhoc/uri/VmVpZGViYXVtLCBUb29tYXM=|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0001-7483-0726|https://orcid.org/0000-0003-2216-6653
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
  2. Seventh Framework Programme |
  3. Deutsche Forschungsgemeinschaft |
  4. National Institute of Environmental Health Sciences |
  5. Projekt DEAL |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 66044 (KBBE 2010-14)
  3. HU 2731/1-1
  4. P30ES019776
  5. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. HERCULES Center
  5. Open Acess Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 66044 (KBBE 2010-14)
  3. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer HU 2731/1-1
  4. 1000 joinedFunding-child
    1000 Förderer National Institute of Environmental Health Sciences |
    1000 Förderprogramm HERCULES Center
    1000 Fördernummer P30ES019776
  5. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Acess Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6429485.rdf
1000 Erstellt am 2021-09-23T11:18:56.835+0200
1000 Erstellt von 266
1000 beschreibt frl:6429485
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2021-09-24T15:02:29.314+0200
1000 Objekt bearb. Fri Sep 24 15:02:17 CEST 2021
1000 Vgl. frl:6429485
1000 Oai Id
  1. oai:frl.publisso.de:frl:6429485 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source