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1000 Titel
  • Exploring and optimizing the neuroplastic effects of anodal transcranial direct current stimulation over the primary motor cortex of older humans
1000 Autor/in
  1. Farnad, Leila |
  2. Ghasemian-Shirvan, Ensiyeh |
  3. mosayebi samani, mohsen |
  4. Kuo, Min-Fang |
  5. Nitsche, Michael |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-31
1000 Erschienen in
1000 Quellenangabe
  • 14(3):622-634
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.brs.2021.03.013 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1935861X21000644?via%3Dihub#appsec1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: tDCS modulates cortical plasticity and has shown potential to improve cognitive/motor functions in healthy young humans. However, age-related alterations of brain structure and functions might require an adaptation of tDCS-parameters to achieve a targeted plasticity effect in older humans and conclusions obtained from young adults might not be directly transferable to older adults. Thus, our study aimed to systematically explore the association between tDCS-parameters and induced aftereffects on motor cortical excitability to determine optimal stimulation protocols for older individuals, as well as to investigate age-related differences of motor cortex plasticity in two different age groups of older adults. METHODS: 32 healthy, volunteers from two different age groups of Young-Old (50–65 years, n = 16) and Old-Old (66–80 years, n = 16) participated in this study. Anodal tDCS was applied over the primary motor cortex, with respective combinations of three intensities (1, 2, and 3 mA) and durations (15, 20, and 30 min), in a sham-controlled cross-over design. Cortical excitability alterations were monitored by single-pulse TMS-induced MEPs until the next day morning after stimulation. RESULTS: All active stimulation conditions resulted in a significant enhancement of motor cortical excitability in both age groups. The facilitatory aftereffects of anodal tDCS did not significantly differ between age groups. We observed prolonged plasticity in the late-phase range for two protocols with the highest stimulation intensity (i.e., 3 mA-20 min, 3 mA-30 min). CONCLUSIONS: Our study highlights the role of stimulation dosage in tDCS-induced neuroplastic aftereffects in the motor cortex of healthy older adults and delivers crucial information about optimized tDCS protocols in the domain of the primary motor cortex. Our findings might set the grounds for the development of optimal stimulation protocols to reinstate neuroplasticity in different cortical areas and induce long-lasting, functionally relevant plasticity in normal aging and in pathological conditions, which would require however systematic tDCS titration studies over respective target areas.
1000 Sacherschließung
lokal TMS
lokal Aging
lokal MEP
lokal tDCS
lokal Neuroplasticity
lokal Motor cortex
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RmFybmFkLCBMZWlsYQ==|https://orcid.org/0000-0001-5146-6749|https://orcid.org/0000-0003-3826-5795|https://orcid.org/0000-0001-9955-0237|https://orcid.org/0000-0002-2207-5965
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. 01EE1501; 01GQ1424E
1000 Förderprogramm
  1. GCBS; TRAINSTIM
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm GCBS; TRAINSTIM
    1000 Fördernummer 01EE1501; 01GQ1424E
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6429557.rdf
1000 Erstellt am 2021-09-29T08:50:34.832+0200
1000 Erstellt von 254
1000 beschreibt frl:6429557
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Fri Oct 01 08:41:00 CEST 2021
1000 Objekt bearb. Thu Sep 30 14:37:44 CEST 2021
1000 Vgl. frl:6429557
1000 Oai Id
  1. oai:frl.publisso.de:frl:6429557 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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