Contribution to the ongoing discussion on fluoride toxicity

  1. Guth, Sabine ORCID logo
  2. Hüser, Stephanie
  3. Roth, Angelika
  4. Degen, Gisela H ORCID logo
  5. Diel, Patrick
  6. Edlund, Karolina ORCID logo
  7. Eisenbrand, Gerhard
  8. Engel, Karl‐Heinz
  9. Epe, Bernd
  10. Grune, Tilman
  11. Heinz, Volker
  12. Henle, Thomas
  13. Humpf, Hans‐Ulrich
  14. Jäger, Henry
  15. Joost, Hans‐Georg
  16. Kulling, Sabine E.
  17. Lampen, Alfonso
  18. Mally, Angela
  19. Marchan, Rosemarie ORCID logo
  20. Marko, Doris
  21. Mühle, Eva
  22. Nitsche, Michael ORCID logo
  23. Röhrdanz, Elke
  24. Stadler, Richard
  25. van Thriel, Christoph ORCID logo
  26. Vieths, Stefan
  27. Vogel, Rudi F.
  28. Wascher, Edmund ORCID logo
  29. Watzl, Carsten ORCID logo
  30. Nöthlings, Ute
  31. Hengstler, Jan ORCID logo

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WeightNameValue
1000 Titel
  • Contribution to the ongoing discussion on fluoride toxicity
1000 Autor/in
  1. Guth, Sabine |
  2. Hüser, Stephanie |
  3. Roth, Angelika |
  4. Degen, Gisela H |
  5. Diel, Patrick |
  6. Edlund, Karolina |
  7. Eisenbrand, Gerhard |
  8. Engel, Karl‐Heinz |
  9. Epe, Bernd |
  10. Grune, Tilman |
  11. Heinz, Volker |
  12. Henle, Thomas |
  13. Humpf, Hans‐Ulrich |
  14. Jäger, Henry |
  15. Joost, Hans‐Georg |
  16. Kulling, Sabine E. |
  17. Lampen, Alfonso |
  18. Mally, Angela |
  19. Marchan, Rosemarie |
  20. Marko, Doris |
  21. Mühle, Eva |
  22. Nitsche, Michael |
  23. Röhrdanz, Elke |
  24. Stadler, Richard |
  25. van Thriel, Christoph |
  26. Vieths, Stefan |
  27. Vogel, Rudi F. |
  28. Wascher, Edmund |
  29. Watzl, Carsten |
  30. Nöthlings, Ute |
  31. Hengstler, Jan |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-06
1000 Erschienen in
1000 Quellenangabe
  • 95(7):2571-2587
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-03072-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241794/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Since the addition of fluoride to drinking water in the 1940s, there have been frequent and sometimes heated discussions regarding its benefits and risks. In a recently published review, we addressed the question if current exposure levels in Europe represent a risk to human health. This review was discussed in an editorial asking why we did not calculate benchmark doses (BMD) of fluoride neurotoxicity for humans. Here, we address the question, why it is problematic to calculate BMDs based on the currently available data. Briefly, the conclusions of the available studies are not homogeneous, reporting negative as well as positive results; moreover, the positive studies lack control of confounding factors such as the influence of well-known neurotoxicants. We also discuss the limitations of several further epidemiological studies that did not meet the inclusion criteria of our review. Finally, it is important to not only focus on epidemiological studies. Rather, risk analysis should consider all available data, including epidemiological, animal, as well as in vitro studies. Despite remaining uncertainties, the totality of evidence does not support the notion that fluoride should be considered a human developmental neurotoxicant at current exposure levels in European countries.
1000 Sacherschließung
gnd 4034904-4 Lebensmitteltoxikologie
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5729-0331|https://frl.publisso.de/adhoc/uri/SMO8c2VyLCBTdGVwaGFuaWU=|https://frl.publisso.de/adhoc/uri/Um90aCwgQW5nZWxpa2E=|https://orcid.org/0000-0002-5034-6195|https://frl.publisso.de/adhoc/uri/RGllbCwgUGF0cmljaw==|https://orcid.org/0000-0002-0276-2143|https://frl.publisso.de/adhoc/uri/RWlzZW5icmFuZCwgR2VyaGFyZA==|https://frl.publisso.de/adhoc/uri/RW5nZWwsIEthcmzigJFIZWlueg==|https://frl.publisso.de/adhoc/uri/RXBlLCBCZXJuZA==|https://frl.publisso.de/adhoc/uri/R3J1bmUsIFRpbG1hbg==|https://frl.publisso.de/adhoc/uri/SGVpbnosIFZvbGtlcg==|https://frl.publisso.de/adhoc/uri/SGVubGUsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/SHVtcGYsIEhhbnPigJFVbHJpY2g=|https://frl.publisso.de/adhoc/uri/SsOkZ2VyLCBIZW5yeQ==|https://frl.publisso.de/adhoc/uri/Sm9vc3QsIEhhbnPigJFHZW9yZw==|https://frl.publisso.de/adhoc/uri/S3VsbGluZywgU2FiaW5lIEUu|https://frl.publisso.de/adhoc/uri/TGFtcGVuLCBBbGZvbnNv|https://frl.publisso.de/adhoc/uri/TWFsbHksIEFuZ2VsYQ==|https://orcid.org/0000-0003-4414-1633|https://frl.publisso.de/adhoc/uri/TWFya28sIERvcmlz|https://frl.publisso.de/adhoc/uri/TcO8aGxlLCBFdmE=|https://orcid.org/0000-0002-2207-5965|https://frl.publisso.de/adhoc/uri/UsO2aHJkYW56LCBFbGtl|https://frl.publisso.de/adhoc/uri/U3RhZGxlciwgUmljaGFyZA==|https://orcid.org/0000-0003-3215-9262|https://d-nb.info/gnd/143949705|https://frl.publisso.de/adhoc/uri/Vm9nZWwsIFJ1ZGkgRi4=|https://orcid.org/0000-0003-3616-9767|https://orcid.org/0000-0001-5195-0995|https://frl.publisso.de/adhoc/uri/TsO2dGhsaW5ncywgVXRl|https://orcid.org/0000-0002-1427-5246
1000 Label
1000 Förderer
  1. Projekt DEAL |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Open Access funding
1000 Dateien
  1. Contribution to the ongoing discussion on fluoride toxicity
    Contribution to the ongoing discussion on fluoride toxicity
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6429656.rdf
1000 Erstellt am 2021-10-01T12:57:36.102+0200
1000 Erstellt von 254
1000 beschreibt frl:6429656
1000 Bearbeitet von 323
1000 Zuletzt bearbeitet Tue Mar 01 11:36:53 CET 2022
1000 Objekt bearb. Tue Mar 01 11:36:53 CET 2022
1000 Vgl. frl:6429656
1000 Oai Id
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