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1000 Titel
  • Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling
1000 Autor/in
  1. Kuhls, Katrin |
  2. Moskalenko, Olga |
  3. Sukiasyan, Anna |
  4. Manukyan, Dezdemonia |
  5. Melik-Andreasyan, Gayane |
  6. Atshemyan, Liana |
  7. Apresyan, Hripsime |
  8. Strelkova, Margarita |
  9. Jaeschke, Anja |
  10. Wieland, Ralf |
  11. Frohme, Marcus |
  12. Cortes, Sofia |
  13. Keshishyan, Ara |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-19
1000 Erschienen in
1000 Quellenangabe
  • 15(4):e000928
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pntd.0009288 |
1000 Ergänzendes Material
  • https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009288#sec024 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Visceral leishmaniasis (VL) is re-emerging in Armenia since 1999 with 167 cases recorded until 2019. The objectives of this study were (i) to determine for the first time the genetic diversity and population structure of the causative agent of VL in Armenia; (ii) to compare these genotypes with those from most endemic regions worldwide; (iii) to monitor the diversity of vectors in Armenia; (iv) to predict the distribution of the vectors and VL in time and space by ecological niche modeling. METHODOLOGY/PRINCIPAL FINDINGS: Human samples from different parts of Armenia previously identified by ITS-1-RFLP as L. infantum were studied by Multilocus Microsatellite Typing (MLMT). These data were combined with previously typed L. infantum strains from the main global endemic regions for population structure analysis. Within the 23 Armenian L. infantum strains 22 different genotypes were identified. The combined analysis revealed that all strains belong to the worldwide predominating MON1-population, however most closely related to a subpopulation from Southeastern Europe, Maghreb, Middle East and Central Asia. The three observed Armenian clusters grouped within this subpopulation with strains from Greece/Turkey, and from Central Asia, respectively. Ecological niche modeling based on VL cases and collected proven vectors (P. balcanicus, P. kandelakii) identified Yerevan and districts Lori, Tavush, Syunik, Armavir, Ararat bordering Georgia, Turkey, Iran and Azerbaijan as most suitable for the vectors and with the highest risk for VL transmission. Due to climate change the suitable habitat for VL transmission will expand in future all over Armenia. CONCLUSIONS: Genetic diversity and population structure of the causative agent of VL in Armenia were addressed for the first time. Further genotyping studies should be performed with samples from infected humans, animals and sand flies from all active foci including the neighboring countries to understand transmission cycles, re-emergence, spread, and epidemiology of VL in Armenia and the entire Transcaucasus enabling epidemiological monitoring.
1000 Sacherschließung
lokal Turkey (country)
lokal Armenia
lokal Azerbaijan
lokal Leishmania infantum
lokal Sand flies
lokal Leishmaniasis
lokal Kala-azar
lokal Armenian people
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4168-8684|https://frl.publisso.de/adhoc/uri/TW9za2FsZW5rbywgT2xnYQ==|https://frl.publisso.de/adhoc/uri/U3VraWFzeWFuLCBBbm5h|https://frl.publisso.de/adhoc/uri/TWFudWt5YW4sIERlemRlbW9uaWE=|https://frl.publisso.de/adhoc/uri/TWVsaWstQW5kcmVhc3lhbiwgR2F5YW5l|https://frl.publisso.de/adhoc/uri/QXRzaGVteWFuLCBMaWFuYQ==|https://orcid.org/0000-0001-8482-1372|https://orcid.org/0000-0001-5705-9327|https://orcid.org/0000-0001-8361-0960|https://orcid.org/0000-0002-2278-610X|https://orcid.org/0000-0001-9063-2682|https://orcid.org/0000-0001-5850-6950|https://frl.publisso.de/adhoc/uri/S2VzaGlzaHlhbiwgQXJh
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
  2. Deutscher Akademischer Austauschdienst |
  3. Fundação para a Ciência e a Tecnologia |
1000 Fördernummer
  1. 01DK14021; 16PGF0170
  2. 1618841
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer 01DK14021; 16PGF0170
  2. 1000 joinedFunding-child
    1000 Förderer Deutscher Akademischer Austauschdienst |
    1000 Förderprogramm -
    1000 Fördernummer 1618841
  3. 1000 joinedFunding-child
    1000 Förderer Fundação para a Ciência e a Tecnologia |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6430240.rdf
1000 Erstellt am 2021-11-15T14:09:47.576+0100
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1000 Zuletzt bearbeitet Mon Nov 15 14:10:47 CET 2021
1000 Objekt bearb. Mon Nov 15 14:10:28 CET 2021
1000 Vgl. frl:6430240
1000 Oai Id
  1. oai:frl.publisso.de:frl:6430240 |
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