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1000 Titel
  • Associations between comorbidities and advanced stage diagnosis of lung, breast, colorectal, and prostate cancer: A systematic review and meta-analysis
1000 Autor/in
  1. Boakye, Daniel |
  2. Günther, Kathrin |
  3. Niedermaier, Tobias |
  4. Haug, Ulrike |
  5. Ahrens, Wolfgang |
  6. Nagrani, Rajini |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-10
1000 Erschienen in
1000 Quellenangabe
  • 75:102054
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-11-10
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.canep.2021.102054 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/abs/pii/S1877782121001715?via%3Dihub#sec0115 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Comorbidities and advanced stage diagnosis (ASD) are both associated with poorer cancer outcomes, but the association between comorbidities and ASD is poorly understood. We summarized epidemiological evidence on the association between comorbidities and ASD of selected cancers in a systematic review and meta-analysis. We searched PubMed and Web of Science databases up to June 3rd, 2021 for studies assessing the association between comorbidities and ASD of lung, breast, colorectal, or prostate cancer. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random-effects models. Also, potential variations in the associations between comorbidities and ASD by cancer type were investigated using random-effects meta-regression. Thirty-seven studies were included in this review, including 8,069,397 lung, breast, colorectal, and prostate cancer patients overall. The Charlson comorbidity index score was positively associated with ASD (stages III–IV) of breast cancer but was inversely associated with ASD of lung cancer (pinteraction = 0.004). Regarding specific comorbidities, diabetes was positively associated with ASD (OR = 1.17, 95%CI = 1.09–1.26), whereas myocardial infarction was inversely associated with ASD (OR = 0.84, 95%CI = 0.75–0.95). The association between renal disease and ASD differed by cancer type (pinteraction < 0.001). A positive association was found with prostate cancer (OR = 2.02, 95%CI = 1.58–2.59) and an inverse association with colorectal cancer (OR = 0.84, 95%CI = 0.70–1.00). In summary, certain comorbidities (e.g., diabetes) may be positively associated with ASD of several cancer types. It needs to be clarified whether closer monitoring for early cancer signs or screening in these patients is reasonable, considering the problem of over-diagnosis particularly relevant in patients with short remaining life expectancy such as those with comorbidities. Also, evaluation of the cost-benefit relationship of cancer screening according to the type and severity of comorbidity (rather than summary scores) may be beneficial for personalized cancer screening in populations with chronic diseases.
1000 Sacherschließung
lokal Advanced stage
lokal Cancer
lokal Comorbidity
lokal Late-stage
lokal Chronic disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4684-0841|https://orcid.org/0000-0001-6347-7154|https://frl.publisso.de/adhoc/uri/TmllZGVybWFpZXIsIFRvYmlhcw==|https://orcid.org/0000-0002-1886-2923|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0002-1708-2319
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Nutzungsvereinbarung
  2. Elsevier_self-archiving policy
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6430337.rdf
1000 Erstellt am 2021-11-19T11:25:00.246+0100
1000 Erstellt von 266
1000 beschreibt frl:6430337
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Thu Nov 10 08:33:00 CET 2022
1000 Objekt bearb. Thu Nov 10 08:32:59 CET 2022
1000 Vgl. frl:6430337
1000 Oai Id
  1. oai:frl.publisso.de:frl:6430337 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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