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1000 Titel
  • Systemic inflammation, innate immunity and pathogenesis after Zika virus infection in cynomolgus macaques are modulated by strain-specificity within the Asian lineage
1000 Autor/in
  1. DE ALWIS, ADAMBERAGE |
  2. Zellweger, Raphael |
  3. Chua, Edmond |
  4. Wang, Lin-Fa |
  5. Chawla, Tanu |
  6. Sessions, October |
  7. Marlier, Damien |
  8. Connolly, John |
  9. von Messling, Veronika |
  10. Anderson, Danielle |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-22
1000 Erschienen in
1000 Quellenangabe
  • 10(1):1457-1470
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1080/22221751.2021.1943536 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300938 |
1000 Ergänzendes Material
  • https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1943536?scroll=top&needAccess=true#supplemental-material-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Zika virus (ZIKV) is an emerging arbovirus with recent global expansion. Historically, ZIKV infections with Asian lineages have been associated with mild disease such as rash and fever. However, recent Asian sub-lineages have caused outbreaks in the South Pacific and Latin America with increased prevalence of neurological disorders in infants and adults. Asian sub-lineage differences may partially explain the range of disease severity observed. However, the effect of Asian sub-lineage differences on pathogenesis remains poorly characterized. Current study conducts a head-to-head comparison of three Asian sub-lineages that are representative of the circulating ancestral mild Asian strain (ZIKV-SG), the 2007 epidemic French Polynesian strain (ZIKV-FP), and the 2013 epidemic Brazil strain (ZIKV-Brazil) in adult Cynomolgus macaques. Animals infected intervenously or subcutaneously with either of the three clinical isolates showed sub-lineage-specific differences in viral pathogenesis, early innate immune responses and systemic inflammation. Despite the lack of neurological symptoms in infected animals, the epidemiologically neurotropic ZIKV sub-lineages (ZIKV-Brazil and/or ZIKV-FP) were associated with more sustained viral replication, higher systemic inflammation (i.e. higher levels of TNFα, MCP-1, IL15 and G-CSF) and greater percentage of CD14+ monocytes and dendritic cells in blood. Multidimensional analysis showed clustering of ZIKV-SG away from ZIKV-Brazil and ZIKV-FP, further confirming sub-lineage differences in the measured parameters. These findings highlight greater systemic inflammation and monocyte recruitment as possible risk factors of adult ZIKV disease observed during the 2007 FP and 2013 Brazil epidemics. Future studies should explore the use of anti-inflammatory therapeutics as early treatment to prevent ZIKV-associated disease in adults.
1000 Sacherschließung
lokal flavivirus
gnd 4188401-2 Virusinfektion
lokal NHP
lokal inflammation
lokal Zika virus
lokal arbovirus
lokal innate immunity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2319-3701|https://orcid.org/0000-0003-1829-058X|https://frl.publisso.de/adhoc/uri/Q2h1YSwgRWRtb25k|https://orcid.org/0000-0003-2752-0535|https://orcid.org/0000-0002-7869-3818|https://orcid.org/0000-0002-1370-2744|https://frl.publisso.de/adhoc/uri/TWFybGllciwgRGFtaWVu|https://orcid.org/0000-0002-9680-3216|https://orcid.org/0000-0002-3972-8723|https://orcid.org/0000-0003-4791-5024
1000 Label
1000 Förderer
  1. National Medical Research Council |
  2. Duke-NUS Medical School |
1000 Fördernummer
  1. MOH-000231; MOH-OFIRG18nov-0004; NMRC /ZRRF/0002/2016
  2. KBrFA/2018/0016
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer MOH-000231; MOH-OFIRG18nov-0004; NMRC /ZRRF/0002/2016
  2. 1000 joinedFunding-child
    1000 Förderer Duke-NUS Medical School |
    1000 Förderprogramm -
    1000 Fördernummer KBrFA/2018/0016
1000 Objektart article
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1000 @id frl:6431664.rdf
1000 Erstellt am 2022-02-18T08:32:55.352+0100
1000 Erstellt von 323
1000 beschreibt frl:6431664
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Mar 04 09:33:17 CET 2022
1000 Objekt bearb. Fri Mar 04 09:21:13 CET 2022
1000 Vgl. frl:6431664
1000 Oai Id
  1. oai:frl.publisso.de:frl:6431664 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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