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1000 Titel
  • C Proteins: Controllers of Orderly Paramyxovirus Replication and of the Innate Immune Response
1000 Autor/in
  1. Siering, Oliver |
  2. Cattaneo, Roberto |
  3. Pfaller, Christian |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-12
1000 Erschienen in
1000 Quellenangabe
  • 14(1):137
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Particles of many paramyxoviruses include small amounts of proteins with a molecular weight of about 20 kDa. These proteins, termed “C”, are basic, have low amino acid homology and some secondary structure conservation. C proteins are encoded in alternative reading frames of the phosphoprotein gene. Some viruses express nested sets of C proteins that exert their functions in different locations: In the nucleus, they interfere with cellular transcription factors that elicit innate immune responses; in the cytoplasm, they associate with viral ribonucleocapsids and control polymerase processivity and orderly replication, thereby minimizing the activation of innate immunity. In addition, certain C proteins can directly bind to, and interfere with the function of, several cytoplasmic proteins required for interferon induction, interferon signaling and inflammation. Some C proteins are also required for efficient virus particle assembly and budding. C-deficient viruses can be grown in certain transformed cell lines but are not pathogenic in natural hosts. C proteins affect the same host functions as other phosphoprotein gene-encoded proteins named V but use different strategies for this purpose. Multiple independent systems to counteract host defenses may ensure efficient immune evasion and facilitate virus adaptation to new hosts and tissue environments.
1000 Sacherschließung
lokal Orthoparamyxovirinae
lokal Paramyxoviridae
lokal budding
lokal replication
lokal ESCRT
lokal nucleocapsid
gnd 4836914-7 Paramyxovirose
lokal defective-interfering RNA
lokal inflammasome
lokal processivity
lokal immune evasion
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. 197785619/B12; R01 AI143791; R21 AI159230
1000 Förderprogramm
  1. SFB 1021, Project B12
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm SFB 1021, Project B12
    1000 Fördernummer 197785619/B12; R01 AI143791; R21 AI159230
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6431723.rdf
1000 Erstellt am 2022-02-21T13:25:51.640+0100
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1000 Zuletzt bearbeitet Thu Feb 24 10:41:30 CET 2022
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