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1000 Titel
  • Immune metabolism in allergies, does it matter?-A review of immune metabolic basics and adaptations associated with the activation of innate immune cells in allergy
1000 Autor/in
  1. Goretzki, Alexandra |
  2. Lin, Yen-Ju |
  3. Schülke, Stefan |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-02
1000 Erschienen in
1000 Quellenangabe
  • 76(11):3314-3331
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/all.14843 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Type I allergies are pathological, type 2 inflammatory immune responses against otherwise harmless environmental allergens that arise from complex interactions between different types of immune cells. Activated immune cells undergo extensive changes in phenotype and function to fulfill their effector functions. Hereby, activation, differentiation, proliferation, migration, and mounting of effector responses require metabolic reprogramming. While the metabolic changes associated with activation of dendritic cells, macrophages, and T cells are extensively studied, data about the metabolic phenotypes of the other cell types critically involved in allergic responses (epithelial cells, eosinophils, basophils, mast cells, and ILC2s) are rather limited. This review briefly covers the basics of cellular energy metabolism and its connection to immune cell function. In addition, it summarizes the current state of knowledge in terms of dendritic cell and macrophage metabolism and subsequently focuses on the metabolic changes associated with activation of epithelial cells, eosinophils, basophils, mast cells, as well as ILC2s in allergy. Interestingly, the innate key cell types in allergic inflammation were reported to change their metabolic phenotype during activation, shifting to either glycolysis (epithelial cells, M1 macrophages, DCs, eosinophils, basophils, acutely activated mast cells), oxidative phosphorylation (M2 macrophages, longer term activated mast cells), or fatty acid oxidation (ILC2s). Therefore, immune metabolism is of relevance in allergic diseases and its connection to immune cell effector function needs to be considered to better understand induction and maintenance of allergic responses. Further progress in this field will likely improve both our understanding of disease pathology and enable new treatment targets/strategies.
1000 Sacherschließung
lokal immune metabolism
lokal allergies
lokal metabolism
gnd 4001257-8 Allergie
lokal oxidative phosphorylation
lokal glycolysis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7078-6406|https://orcid.org/0000-0002-0761-9506|https://orcid.org/0000-0002-9674-5116
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. SCHU2951/4; SCHE637/4-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SCHU2951/4; SCHE637/4-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6431825.rdf
1000 Erstellt am 2022-02-28T14:05:43.443+0100
1000 Erstellt von 323
1000 beschreibt frl:6431825
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Mar 09 09:41:39 CET 2022
1000 Objekt bearb. Wed Mar 09 09:41:26 CET 2022
1000 Vgl. frl:6431825
1000 Oai Id
  1. oai:frl.publisso.de:frl:6431825 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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