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1000 Titel
  • Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
1000 Autor/in
  1. Lin, Yen-Ju |
  2. Goretzki, Alexandra |
  3. Schülke, Stefan |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-01
1000 Erschienen in
1000 Quellenangabe
  • 12:790658
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2021.790658 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671807/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and inflammation are IgE-producing plasma cells and Th2 cells. The acute activation of T and B cells, their differentiation into effector cells, as well as the formation of immunological memory are paralleled by distinct changes in cellular metabolism. Understanding the functional consequences of these metabolic changes is the focus of a new research field termed “immune metabolism”. Currently, the contribution of metabolic changes in T and B cells to either the development or maintenance of allergies is not completely understood. Therefore, this mini review will introduce the fundamentals of energy metabolism, its connection to immune metabolism, and subsequently focus on the metabolic phenotypes of IL-4-activated B cells and Th2 cells.
1000 Sacherschließung
lokal Warburg metabolism
lokal immune metabolism
lokal allergies
lokal metabolism
gnd 4001257-8 Allergie
lokal oxidative phosphorylation
lokal fatty acid oxidation (FAO)
lokal glycolysis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-0761-9506|https://orcid.org/0000-0001-7078-6406|https://orcid.org/0000-0002-9674-5116
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. SCHU2951/4; SCHE637/4
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SCHU2951/4; SCHE637/4
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432019.rdf
1000 Erstellt am 2022-03-07T13:54:31.215+0100
1000 Erstellt von 323
1000 beschreibt frl:6432019
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2022-03-18T07:43:33.049+0100
1000 Objekt bearb. Fri Mar 18 07:43:19 CET 2022
1000 Vgl. frl:6432019
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432019 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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