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Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections

  1. Richter, Enrico
  2. Al Arashi, Doaa
  3. Schulte, Bianca ORCID logo
  4. Bode, Christian ORCID logo
  5. Marx, Benjamin
  6. Aldabbagh, Souhaib ORCID logo
  7. Schlüter, Celina
  8. Kümmerer, Beate Mareike ORCID logo
  9. Oldenburg, Johannes
  10. Funk, Markus B.
  11. Putensen, Christian
  12. Schmithausen, Ricarda Maria ORCID logo
  13. Hartmann, Gunther ORCID logo
  14. Eis-Hübinger, Anna ORCID logo
  15. Streeck, Hendrik ORCID logo

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1000 Titel
  • Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections
1000 Autor/in
  1. Richter, Enrico |
  2. Al Arashi, Doaa |
  3. Schulte, Bianca |
  4. Bode, Christian |
  5. Marx, Benjamin |
  6. Aldabbagh, Souhaib |
  7. Schlüter, Celina |
  8. Kümmerer, Beate Mareike |
  9. Oldenburg, Johannes |
  10. Funk, Markus B. |
  11. Putensen, Christian |
  12. Schmithausen, Ricarda Maria |
  13. Hartmann, Gunther |
  14. Eis-Hübinger, Anna |
  15. Streeck, Hendrik |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-05-25
1000 Erschienen in
1000 Quellenangabe
  • 48(3):154-160
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1159/000515841 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216035/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The SARS-CoV-2 pandemic has challenged many of our current routine practices in the treatment and care of patients. Given the critical importance of blood donation and transfusion we analyzed 92 blood samples of individuals infected with SARS-CoV-2 stratified by symptoms. STUDY DESIGN AND METHODS: We therefore tested blood samples for SARS-CoV-2 via RT-PCR targeting the E gene. In addition, we tested each blood sample for anti-SARS-CoV-2 IgG antibodies via ELISA and performed plaque reduction neutralization tests. RESULTS: SARS-CoV-2 RNA was absent in the blood of mild to asymptomatic patients (57 individuals) and only detectable in individuals with severe COVID-19 who were admitted to the intensive care unit (35 individuals) (n = 6/92 [6.5%]; p = 0.023 Fisher’s exact test). Interestingly, anti-spike IgG antibodies were not significantly higher in intensive care unit patients compared to mild patients, but we found that their neutralizing capacity was disproportionately increased (p < 0.001). CONCLUSION: Our observations support the hypothesis that there are no potential hazards from blood or plasma transfusion of SARS-CoV-2-positive individuals with mild flu-like symptoms and more importantly of asymptomatic individuals.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Plasma
lokal Blood donation
lokal Virus safety
lokal Blood safety
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UmljaHRlciwgRW5yaWNvICAgIA==|https://frl.publisso.de/adhoc/uri/ICBBbCBBcmFzaGksIERvYWEgICAgIA==|https://orcid.org/0000-0003-1096-3751|https://orcid.org/0000-0002-0830-870X|https://frl.publisso.de/adhoc/uri/ICBNYXJ4LCBCZW5qYW1pbiAgICAg|https://orcid.org/0000-0002-6289-1756|https://frl.publisso.de/adhoc/uri/IFNjaGzDvHRlciwgQ2VsaW5hIA==|https://orcid.org/0000-0002-9011-2764|https://frl.publisso.de/adhoc/uri/IE9sZGVuYnVyZywgSm9oYW5uZXMgIA==|https://d-nb.info/gnd/1251987540|https://frl.publisso.de/adhoc/uri/ICBQdXRlbnNlbiwgQ2hyaXN0aWFuICAg|https://orcid.org/0000-0002-3736-8672|https://orcid.org/0000-0003-1021-2018|https://orcid.org/0000-0001-9010-8805|https://orcid.org/0000-0002-0335-6390
1000 Label
1000 Förderer
  1. Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432183.rdf
1000 Erstellt am 2022-03-14T09:58:53.548+0100
1000 Erstellt von 323
1000 beschreibt frl:6432183
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Mar 31 08:08:31 CEST 2022
1000 Objekt bearb. Tue Mar 29 12:46:25 CEST 2022
1000 Vgl. frl:6432183
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432183 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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