AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

  1. Ferastraoaru, Denisa ORCID logo
  2. Bax, Heather ORCID logo
  3. Bergmann, Christoph ORCID logo
  4. Capron , monique ORCID logo
  5. Castells, Mariana ORCID logo
  6. Dombrowicz, David ORCID logo
  7. Fiebiger, Edda ORCID logo
  8. Gould, Hannah ORCID logo
  9. Hartmann, Karin ORCID logo
  10. Jappe, Uta
  11. Jordakieva, Galateja ORCID logo
  12. Josephs, Debra ORCID logo
  13. Levi-Schaffer, Francesca ORCID logo
  14. Mahler, Vera
  15. Poli, Aurelie
  16. Rosenstreich, David ORCID logo
  17. Roth-Walter, Franziska ORCID logo
  18. Shamji, Mohamed ORCID logo
  19. Steveling, Esther Helen ORCID logo
  20. Turner, Michelle C ORCID logo
  21. Untersmayr, Eva ORCID logo
  22. Karagiannis, Sophia ORCID logo
  23. Jensen-Jarolim, Erika ORCID logo

Download
Upload.pdf 1,45MB
WeightNameValue
1000 Titel
  • AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
1000 Autor/in
  1. Ferastraoaru, Denisa |
  2. Bax, Heather |
  3. Bergmann, Christoph |
  4. Capron , monique |
  5. Castells, Mariana |
  6. Dombrowicz, David |
  7. Fiebiger, Edda |
  8. Gould, Hannah |
  9. Hartmann, Karin |
  10. Jappe, Uta |
  11. Jordakieva, Galateja |
  12. Josephs, Debra |
  13. Levi-Schaffer, Francesca |
  14. Mahler, Vera |
  15. Poli, Aurelie |
  16. Rosenstreich, David |
  17. Roth-Walter, Franziska |
  18. Shamji, Mohamed |
  19. Steveling, Esther Helen |
  20. Turner, Michelle C |
  21. Untersmayr, Eva |
  22. Karagiannis, Sophia |
  23. Jensen-Jarolim, Erika |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-17
1000 Erschienen in
1000 Quellenangabe
  • 10:32
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13601-020-00335-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366896/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.
1000 Sacherschließung
lokal Cancer
gnd 4001257-8 Allergie
lokal Malignancy
lokal Atopy
lokal Allergy diagnosis
lokal IgE
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9799-4800|https://orcid.org/0000-0003-0432-4160|https://orcid.org/0000-0002-2076-8813|https://orcid.org/0000-0001-5625-5158|https://orcid.org/0000-0001-6451-0163|https://orcid.org/0000-0002-0485-8923|https://orcid.org/0000-0003-3385-0100|https://orcid.org/0000-0003-0411-688X|https://orcid.org/0000-0002-4595-8226|https://d-nb.info/gnd/1076111688|https://orcid.org/0000-0001-5884-8256|https://orcid.org/0000-0002-5610-9123|https://orcid.org/0000-0003-0620-2810|https://d-nb.info/gnd/1115010409|https://frl.publisso.de/adhoc/uri/ICBQb2xpLCBBdXJlbGllIA==|https://orcid.org/0000-0003-0612-3450|https://orcid.org/0000-0001-5005-9228|https://orcid.org/0000-0003-3425-3463|https://orcid.org/0000-0002-4303-0571|https://orcid.org/0000-0002-6431-1997|https://orcid.org/0000-0002-1963-499X|https://orcid.org/0000-0002-4100-7810|https://orcid.org/0000-0003-4019-5765
1000 Label
1000 Förderer
  1. European Academy of Allergy and Clinical Immunology |
  2. Austrian Science Fund |
1000 Fördernummer
  1. -
  2. F4606-B28
1000 Förderprogramm
  1. -
  2. FWF grant
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Academy of Allergy and Clinical Immunology |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Austrian Science Fund |
    1000 Förderprogramm FWF grant
    1000 Fördernummer F4606-B28
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432457.rdf
1000 Erstellt am 2022-03-22T16:48:29.552+0100
1000 Erstellt von 323
1000 beschreibt frl:6432457
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2022-04-21T10:23:03.631+0200
1000 Objekt bearb. Thu Apr 21 10:22:39 CEST 2022
1000 Vgl. frl:6432457
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432457 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source