Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

  1. Holland, Christian ORCID logo
  2. Ramirez Flores, Ricardo Omar ORCID logo
  3. Myllys, Maiju ORCID logo
  4. Hassan, Reham ORCID logo
  5. Edlund, Karolina ORCID logo
  6. Hofmann, Ute
  7. Marchan, Rosemarie ORCID logo
  8. Cadenas, Cristina ORCID logo
  9. Reinders, Joerg ORCID logo
  10. Hoehme, Stefan ORCID logo
  11. Seddek, Abdel-latif
  12. Dooley, Steven
  13. Keitel, Verena ORCID logo
  14. Godoy, Patricio ORCID logo
  15. Begher-Tibbe, Brigitte
  16. Trautwein, Christian
  17. Rupp, Christian
  18. Mueller, Sebastian
  19. Longerich, Thomas
  20. Hengstler, Jan ORCID logo
  21. Saez-Rodriguez, Julio ORCID logo
  22. Ghallab, Ahmed ORCID logo

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Hepatology Communications - 2021 - Holland - Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals.pdf 3,39MB
WeightNameValue
1000 Titel
  • Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
1000 Autor/in
  1. Holland, Christian |
  2. Ramirez Flores, Ricardo Omar |
  3. Myllys, Maiju |
  4. Hassan, Reham |
  5. Edlund, Karolina |
  6. Hofmann, Ute |
  7. Marchan, Rosemarie |
  8. Cadenas, Cristina |
  9. Reinders, Joerg |
  10. Hoehme, Stefan |
  11. Seddek, Abdel-latif |
  12. Dooley, Steven |
  13. Keitel, Verena |
  14. Godoy, Patricio |
  15. Begher-Tibbe, Brigitte |
  16. Trautwein, Christian |
  17. Rupp, Christian |
  18. Mueller, Sebastian |
  19. Longerich, Thomas |
  20. Hengstler, Jan |
  21. Saez-Rodriguez, Julio |
  22. Ghallab, Ahmed |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-28
1000 Erschienen in
1000 Quellenangabe
  • 6(1):161-177
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/hep4.1797 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710791/ |
1000 Ergänzendes Material
  • https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1797#support-information-section |
  • https://zenodo.org/record/5076487#.YkLzHS3P2Uk |
  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE166868 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene-expression data from 372 patients were compared with data from acute and chronic mouse models consisting of 227 mice, and additionally to nine published gene sets of chronic mouse models. Genes consistently altered in humans and mice were mapped to liver cell types based on single-cell RNA-sequencing data and validated by immunostaining. Considering the top differentially expressed genes, the similarity between humans and mice varied among the mouse models and depended on the period of damage induction. The highest recall (0.4) and precision (0.33) were observed for the model with 12-months damage induction by CCl4 and by a Western diet, respectively. Genes consistently up-regulated between the chronic CCl4 model and human CLDs were enriched in inflammatory and developmental processes, and mostly mapped to cholangiocytes, macrophages, and endothelial and mesenchymal cells. Down-regulated genes were enriched in metabolic processes and mapped to hepatocytes. Immunostaining confirmed the regulation of selected genes and their cell type specificity. Genes that were up-regulated in both acute and chronic models showed higher recall and precision with respect to human CLDs than exclusively acute or chronic genes. CONCLUSION: Similarly regulated genes in human and mouse CLDs were identified. Despite major interspecies differences, mouse models detected 40% of the genes significantly altered in human CLD. The translational relevance of individual genes can be assessed at https://saezlab.shinyapps.io/liverdiseaseatlas/.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-3060-5786|https://orcid.org/0000-0003-0087-371X|https://orcid.org/0000-0001-9117-4572|https://orcid.org/0000-0002-6569-7676|https://orcid.org/0000-0002-0276-2143|https://frl.publisso.de/adhoc/uri/SG9mbWFubiwgVXRl|https://orcid.org/0000-0003-4414-1633|https://orcid.org/0000-0003-3374-6418|https://orcid.org/0000-0003-1025-7849|https://orcid.org/0000-0002-9716-9587|https://frl.publisso.de/adhoc/uri/U2VkZGVrLCBBYmRlbC1sYXRpZg==|https://frl.publisso.de/adhoc/uri/RG9vbGV5LCBTdGV2ZW4=|https://orcid.org/0000-0003-1383-7662|https://orcid.org/0000-0001-7882-5369|https://frl.publisso.de/adhoc/uri/QmVnaGVyLVRpYmJlLCBCcmlnaXR0ZQ==|https://frl.publisso.de/adhoc/uri/VHJhdXR3ZWluLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/UnVwcCwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/TXVlbGxlciwgU2ViYXN0aWFu|https://frl.publisso.de/adhoc/uri/TG9uZ2VyaWNoLCBUaG9tYXM=|https://orcid.org/0000-0002-1427-5246|https://orcid.org/0000-0002-8552-8976|https://orcid.org/0000-0003-0695-3403
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
  2. European Union |
1000 Fördernummer
  1. 031L0045, 031L0049, 031L0052
  2. 116030; 681002
1000 Förderprogramm
  1. LiSyM
  2. TransQST; EU-ToxRisk
1000 Dateien
  1. Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
    Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm LiSyM
    1000 Fördernummer 031L0045, 031L0049, 031L0052
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm TransQST; EU-ToxRisk
    1000 Fördernummer 116030; 681002
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432654.rdf
1000 Erstellt am 2022-03-29T14:05:57.281+0200
1000 Erstellt von 254
1000 beschreibt frl:6432654
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Apr 04 11:09:25 CEST 2022
1000 Objekt bearb. Mon Apr 04 11:09:14 CEST 2022
1000 Vgl. frl:6432654
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432654 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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