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1000 Titel
  • Kinetic Fingerprinting Links Bacteria-Phage Interactions with Emergent Dynamics: Rapid Depletion of Klebsiella pneumoniae Indicates Phage Synergy
1000 Autor/in
  1. Lößner, Holger |
  2. Schlattmeier, Insea |
  3. Anders-Maurer, Marie |
  4. Bekeredjian-Ding, Isabelle |
  5. Rohde, Christine |
  6. Wittmann, Johannes |
  7. Pokalyuk, Cornelia |
  8. Krut, Oleg |
  9. Kamp, Christel |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-14
1000 Erschienen in
1000 Quellenangabe
  • 9(7):408
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/antibiotics9070408 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400656/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The specific temporal evolution of bacterial and phage population sizes, in particular bacterial depletion and the emergence of a resistant bacterial population, can be seen as a kinetic fingerprint that depends on the manifold interactions of the specific phage–host pair during the course of infection. We have elaborated such a kinetic fingerprint for a human urinary tract Klebsiella pneumoniae isolate and its phage vB_KpnP_Lessing by a modeling approach based on data from in vitro co-culture. We found a faster depletion of the initially sensitive bacterial population than expected from simple mass action kinetics. A possible explanation for the rapid decline of the bacterial population is a synergistic interaction of phages which can be a favorable feature for phage therapies. In addition to this interaction characteristic, analysis of the kinetic fingerprint of this bacteria and phage combination revealed several relevant aspects of their population dynamics: A reduction of the bacterial concentration can be achieved only at high multiplicity of infection whereas bacterial extinction is hardly accomplished. Furthermore the binding affinity of the phage to bacteria is identified as one of the most crucial parameters for the reduction of the bacterial population size. Thus, kinetic fingerprinting can be used to infer phage–host interactions and to explore emergent dynamics which facilitates a rational design of phage therapies.
1000 Sacherschließung
lokal emergence
lokal resistance
lokal kinetic fingerprint
lokal Klebsiella pneumoniae
gnd 1070945714 Phagentherapie
lokal mathematical modeling
lokal phage therapy
lokal population dynamics
lokal synergistic interaction
lokal phage
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://d-nb.info/gnd/128768282|https://frl.publisso.de/adhoc/uri/IFNjaGxhdHRtZWllciwgSW5zZWEgICAgICA=|https://frl.publisso.de/adhoc/uri/QW5kZXJzLU1hdXJlciwgTWFyaWUgIA==|https://orcid.org/0000-0001-6646-5888|https://frl.publisso.de/adhoc/uri/Um9oZGUsIENocmlzdGluZQ==|https://orcid.org/0000-0002-7275-9927|https://orcid.org/0000-0001-8462-8791|https://orcid.org/0000-0002-2394-4413|https://orcid.org/0000-0001-9997-6772
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1000 Erstellt am 2022-03-30T12:09:20.177+0200
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